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Dermpath-India

Pathology of Syringomatous

Carcinoma (Eccrine Carcinoma ;

Syringoid Carcinoma)

Dr Sampurna Roy MD       

 

                                                                                                                      

 

[Syringoid Eccrine Carcinoma ; Sclerosing Sweat gland Carcinoma ; Eccrine Syringomatous Carcinoma ; Eccrine epithelioma]

 

A rare type of locally aggressive sweat gland carcinoma which was originally described as a basal cell carcinoma with eccrine differentiation (eccrine epithelioma) by Freeman et al in 1969  

This tumour was later reported as eccrine syringomatous carcinoma by other authors. 
                                  

Tumour presents as a plaque or firm nodule on the scalp, extremities or trunk of middle aged adults.

Aggressive local recurrence is common. Distant metastasis is usually rare.
 
Microscopic features:

 

Infiltrating tumour located in the dermis ;

May invade into the subcutaneous fat and muscle ;

Composed of solid nests , cords and small tubules lined by basaloid cells ;

Tubules may contain PAS positive, diastase resistant, alcian blue positive material ;

Some ducts demonstrate tail-like extension resembling syringoma.

This feature is also present in microcystic adnexal carcinoma (MAC)  ;

Clear cell variant has been reported ;

Backround stroma is usually desmoplastic in nature ;

Perineural invasion is often identified ;

Cytological atypia not always prominent ; Mitotic activity is not significant.
 

Differential diagnosis : 

Syringoma, basal cell carcinoma,  microcystic adnexal carcinoma , adenoid cystic carcinoma, metastatic carcinoma.

Syringomatous carcinoma is distinguished from MAC on the basis of a lack of follicular (keratocyst, hair germ, matricial) or sebaceous differentiation.

According to some authors Syringomatous carcinoma is part of the spectrum of MAC.    

 

Further reading:

Syringomatous carcinoma: case report of a rare tumor entity.

Syringomatous carcinoma on the leg.

Multiple syringoid eccrine carcinomas with a long-term exposure to X-rays.

Syringoid eccrine carcinoma: a clinicopathological and immunohistochemical study of four cases.

Sclerosing syringoid carcinoma of the finger.

Syringoid eccrine carcinoma: Case report of a rare tumor occasionally detected in the vulva.

Syringoid eccrine carcinoma of external auditory canal. A case report.

A unique association of clinical "persistent müllerian duct syndrome" and syringoid carcinoma of the perineal-scrotal skin: a consequence of urologic surgery?

Syringoid eccrine carcinoma of external auditory canal. A case report.

 


 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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