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Pathology of Tumour of the

Follicular Infundibulum 

Dr Sampurna Roy MD

January 2016


Benign sweat gland tumours


Hydrocystoma -Eccrine/Apocrine


Eccrine/Apocrine naevus

Eccrine  Angiomatous Hamartoma

Porokeratotic  eccrine ostial naevus

Benign Neoplasms:

Syringo cystadenoma Papilliferum

Hidradenoma Papilliferum

Nipple Adenoma




Chondroid Syringoma (benign mixed tumour)



Apocrine adenoma

Papillary eccrine adenoma

Syringo fibroadenoma

Malignant sweat gland tumour 

Low grade:

Microcystic adnexal carcinoma

Eccrine epithelioma

Adenoid cystic carcinoma

Mucinous  carcinoma

Primary extramammary Paget’s disease

Intermediate grade:


Digital papillary adenocarcinoma

High grade:

Hidradeno carcinoma

Apocrine adenocarcinoma

Eccrine ductal carcinoma

Spiradeno carcinoma

Malignant cylindroma

Sebaceous tumours

Fordyce's Spots


Tumour of the follicular infundibulum (TFI) is a simple follicular acanthoma with characteristic histopathologic features.

Classified as:

(1) solitary tumours,

(2) eruptive tumours,

(3) TFI - associated with other lesions of Cowden's disease,

(4) TFI- associated with a single tumour such as nevus sebaceus, and

(5) TFI-like epidermal changes.

Clinically presents as a small asymptomatic, smooth or slightly keratotic papule or plaque.

Sites:  Head and neck or upper chest.

Microscopic features:


Symmetrical tumour with plate-like growth pattern of the squamous cell (similar to isthmic or outer root sheath epithelium) parallel to the surface epithelium ;

Multiple attachments to the epidermis ;

Basal cell palisade ;

Acanthotic epithelium eosinophilic and pale staining than the overlying epidermis ;

Small ducts and microcavities with keratin in the lesion; PAS- positive basement membrane.

Visit: Cowden's syndrome


Differential diagnosis: 

Inverted follicular keratoses ; 

Trichilemmomas  ; 

Plaque-like seborrheic keratosis ;   

Superficial basal cell carcinoma; 

Multiple infundibular tumors of the head and neck.  


Further reading:

Solitary and multiple tumors of follicular infundibulum: a review of 168 cases with emphasis on staining patterns and clinical variants.

Eruptive tumors of the follicular infundibulum presenting as hypopigmented macules on the buttocks of two Black African males.

A case of tumor of the follicular infundibulum with sebaceous differentiation.

Tumor of follicular infundibulum is Basal cell carcinoma.

Tumor of the follicular infundibulum: an epidermal reaction pattern?

[Vitiligoid hypopigmented macules and tumor of the follicular infundibulum].

Multiple tumors of the follicular infundibulum. 

Coexistence of tumor of the follicular infundibulum with an unusual trichilemmal tumor.

Clinicopathological report Periocular tumour of the follicular infundibulum.

Tumor of the follicular infundibulum with sebaceous differentiation.

Tumor of the follicular infundibulum. Study of determining follicular differentiation.

Multiple tumors of follicular infundibulum with sweat duct differentiation.
Tumor of the follicular infundibulum: a clinicopathologic study.:

A tumor of follicular infundibulum. ; Dermatopathology ;; Gallbladder Pathology Online ; Surgical ; Dermpath-India ; Infectious Disease Online ; Pathology Quiz Online ; Paediatric Pathology Online ; Pancreatic Pathology Online ; Paraganglioma-Online ; Endocrine Pathology Online ; Eye Pathology Online ; Ear Pathology Online ; Cardiac Path Online ; Pulmonary Pathology OnlineLung Tumour Online ; Mesothelioma-Online ; Nutritional Pathology Online ; Environmental Pathology Online ; Soft Tissue Tumour Online-India ; GI Path Online-India  ; Case Index ; E-book - History of Medicine with special reference to India; Microscope – Seeing the Unseen

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


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Histology of the Normal Skin


Gross examination of  the skin specimen

Reporting of biopsies taken for Inflammatory Skin Diseases

Lichenoid (Interface)Tissue Reaction Pattern

Psoriasiform Reaction Pattern

Vesiculobullous Reaction Pattern

Spongiotic Reaction Pattern

Vascular Diseases: Various forms of Vasculitis

Lichen planus-like  lesions

Lichen Nitidus

Bullous Pemphigoid

Dermatitis Herpetiformis

Hailey-Hailey Disease 

Granulomatous Reaction Pattern of the Skin

Granuloma Annulare

Necrobiosis Lipoidica

Necrobiotic Xanthogranuloma   

Rheumatoid Nodule

Lupus Vulgaris

Cutaneous Sarcoidosis

Melkersson Rosenthal Syndrome

Annular Elastolytic Giant Cell Granuloma

Skin lesion in Crohn's Disease

Blastomycosis-like pyoderma

Foreign body granuloma


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