Pathology of Warty Dyskeratoma

"A cup shaped, well circumscribed skin lesion with acantholytic and dyskeratotic cells"

Dr Sampurna Roy MD

Syn: Focal Acantholytic Dyskeratosis

Warty dyskeratoma is a rare, benign tumour.

Graham and Helwig first described warty dyskeratoma as isolated Darier's disease in 1954.

It was called warty dyskeratoma by Szymanski in 1957.

According to some authors, majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm.

On the basis of this finding, the term follicular dyskeratoma has been suggested.

These are rare usually solitary lesions with an umbilicated center.

Age:  Usually occur in middle aged or elderly patients.

Site: Located on the head and neck region and rarely in the oral region.

Predisposing factor : Viral infection, smoking, autoimmunity, and ultraviolet light

Differential diagnosis:  Darier’s disease, acantholytic squamous cell carcinoma, and keratoacanthoma.

[Pathology Infographic]- A cup shaped skin lesion- Warty Dyskeratoma

Note: Acantholytic dyskeratosis is a histopathologic pattern defined by a hyperkeratotic and parakeratotic epidermis with intraepidermal clefts containing acantholytic and dyskeratotic keratinocytes.

These features may be present in :

Warty dyskeratoma ; Darier disease ; Grover disease ; Hailey Hailey disease ; Acantholytic and dyskeratotic epidermal nevus, Focal acantholytic dyskeratosis ; Acantholytic solar keratosis ; Vulval and anal acantholytic dyskeratosis.

Dermatopathology Case 120

Warty dyskeratoma involving two adjoining follicles.

Warty dyskeratoma—“follicular dyskeratoma”: Analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm

Multiple warty dyskeratomas of the scalp

Multiple warty dyskeratomas on the scalp.

Warty dyskeratoma: a benign cutaneous tumor resembling Darier's disease microscopically

Warty dyskeratoma or "follicular dykeratoma": a clinicopathologic features of a new entity.

Warty dyskeratoma--"follicular dyskeratoma": analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm.