Pathology of Warty
"A cup shaped, well circumsribed skin
lesion with acantholytic and dyskeratotic cells"
Syn: Focal Acantholytic Dyskeratosis
Warty dyskeratoma is a rare, benign tumour.
Graham and Helwig first described warty dyskeratoma as isolated Darier's disease in 1954. It was called warty dyskeratoma by Szymanski in 1957.
According to some authors, majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm.
On the basis of this finding, the term follicular dyskeratoma has been suggested.
These are rare usually solitary lesions with an umbilicated center.
Age: Usually occur in middle aged or elderly patients.
Site: Located on the head and neck regionand rarely in the oral region.
Predisposing factor : Viral infection, smoking, autoimmunity, and ultraviolet light
Differential diagnosis: Darier’s disease, acantholytic squamous cell carcinoma, and keratoacanthoma.
Note: Acantholytic dyskeratosis is a histopathologic pattern defined by a hyperkeratotic and parakeratotic epidermis with intraepidermal clefts containing acantholytic and dyskeratotic keratinocytes.
These features may be present in :
Warty dyskeratoma ; Darier disease ; Grover disease ; Hailey Hailey disease ; Acantholytic and dyskeratotic epidermal nevus, Focal acantholytic dyskeratosis ; Acantholytic solar keratosis ; Vulval and anal acantholytic dyskeratosis.
Warty dyskeratoma—“follicular dyskeratoma”: Analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm
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