GI Path Online
Pathology of Acute Gastritis
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is an acute mucosal inflammatory process usually of a transient
Stress (burn, trauma).
Following surgery (distal gastrectomy)
mechanism of action:
- Decreased production of surface bicarbonate buffer.
- Reduced mucosal blood flow causing disruption of mucous layer.
- Damage to mucosal epithelium.
Histopathological features in acute gastritis:
Edema in lamina propria; Slight hyperemia in the interfoveolar area ;
Surface epithelium is intact ; Scattered neutrophils within mucosal
epithelial cells - this signifies active inflammation.
-With more severe mucosal damage, erosion and hemorrhage develops.
[Erosion is defined as loss of superficial epithelium causing a defect in the mucosa that does not cross the muscularis mucosa.]
-Lesion is acccompanied by a dense acute inflammatory infiltrate and extrusion of fibrin, containing purulent exudate into the lumen.
-Deep mucosa (glandular zone) is usually unaffected unless stress ulcer results due to local necrosis.
-Crypts may be dilated & filled with acute inflammatory cells in
Epithelial regeneration ; Elongation of pit ; Pseudostratified appearance of superficial epithelium; Residual cluster of neurtrophils in the pit ; Residual cluster of neutrophils in the pit.
Pathologists should be careful not to diagnose regenerative changes as
Regular glands arranged parallel to one another ;
Lamina propria separating the glands ;
Basally located nucleii ; Basophilic cytoplasm ;
Increased nuclear cytoplasmic ratio ;
Increased mitotic activity.
Summary of histological
-Massive mucosal necrosis
Rare types of acute