Custom Search

       

 

Pulmonary Pathology Online

Pathology of Acinic Cell Carcinoma (Fechner Tumour) of the Lung

 Dr Sampurna Roy MD  

 

                                                                                                                      

 

Primary acinic cell carcinomas of the lung are rare tumours, usually presenting in adulthood as parenchymal or endobronchial masses.

The tumour has also been reported in children. 

Histologically, the tumours are composed of clear cells with abundant granular cytoplasm growing as solid sheets with focal acinar, microcystic, and papillocystic areas.  

 

These lesions are generally recognized by their morphological pattern and the presence of large cells with abundant bright cytoplasm and periodic acid-Schiff (PAS)-positive, diastase-resistant cytoplasmic granules.

Signet cell formation sometimes occurs. 

Electron microscopic examination reveals abundant secretory granules.

Immunohistochemical stains are of limited value in this tumour.

Immunohistochemical stains may show strong positivity of the tumor cells for low-molecular-weight cytokeratins and epithelial membrane antigen (EMA).

In some cases focal weak cytoplasmic positivity has been observed with alpha-1-antichymotrypsin and with amylase.

Stains for vimentin, S-100 protein, chromogranin, and lysozyme are usually negative.

Because of their relatively indolent behavior and favorable prognosis, primary acinic cell carcinoma of the lung must be distinguished from other primary and metastatic clear cell tumours of the lung.

Further reading:

Acinic cell carcinoma of the lung ("Fechner tumor"). A clinicopathologic, immunohistochemical, and ultrastructural study of five cases.

Acinic cell carcinoma: an unusual cause of bronchial obstruction in a child.

Fine-needle aspiration cytology of bronchial acinic cell carcinoma: a case report.

Primary acinic cell carcinoma of the lung with lymph node metastasis.

Acinic cell carcinoma of the lung with metastasis to lymph nodes.

Acinic cell carcinoma of the trachea: report of a case.

Acinic cell carcinoma of the trachea.

Acinic cell carcinoma of the trachea--a case report.

Predominantly mucous-differentiated acinic cell adenocarcinoma of the trachea

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 

 


 

 

Histopathology-India.net

 

Pathopedia-India.com

 

Surgical Pathology.com

 

Pathology-India.com

 

Dermpath-India

 

Infectious Disease Online

 

Pathology Quiz Online 

 

Paediatric Pathology Online

 

Pancreatic Pathology Online

 

Paraganglioma-Online

 

Endocrine Pathology Online

 

Eye Pathology Online

 

Ear Pathology Online

 

Cardiac Path Online

 

Pulmonary Pathology Online

 

Lung Tumour Online

 

Mesothelioma-Online

 

Nutritional Pathology Online

 

Environmental Pathology Online

 

Soft Tissue Tumour Online

 

GI Path Online-India

 

Gallbladder Pathology Online

 

E-book - History of Medicine  

 

Microscope - Seeing the Unseen

 

 roypath.in

 

 

Disclaimer

Privacy Policy  

Advertising Policy

Copyright 2017  histopathology-india.net