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Pathology of Adenovirus

Dr Sampurna Roy MD

 

                                                                                                                      

 

 

Adenoviruses were first isolated in 1953 by Rowe and co-workers from human adenoids removed at surgery.

There are 51 immunologically distinct human adenovirus serotypes - (6 species: Human adenovirus A through F).

Many serotypes are not linked to a specific disease.

Human adenoviruses have a capsid with icosahedral symmetry.

Rodlike structures with knobs at the ends protrude from the capsid.

Image Link [This image shows gold clusters (bright yellow) bound to the knob protein on adenovirus.]

The genome of the virus is a double-stranded DNA linear molecule.

When infecting cells in vitro, adenoviruses are capable of lytic infection, latent infection, and transformation.

Because of the ability to transform cells and to produce tumours in rodents, they have been considered possible human tumour viruses, but up to now there has been no evidence that links adenoviruses to human tumours.

Adenoviruses are associated with the following diseases:

- Coryza and pharyngitis in infants ;

- Upper respiratory disease ;

- Pharyngoconjunctival fever ;  

- Hemorrhagic cystitis in children ;

- Acute respiratory disease and pneumonia in young adults  ;

- Epidemic keratoconjunctivitis ;

- Pneumonia in immunocompromised and normal adults.

 

Adenoviruses that are difficult to culture have been associated with 7% to 17% of cases of diarrhea in children.

Adenovirus pneumonia is characterized by necrotizing bronchitis and bronchiolitis. 

There is intense necrosis and desquamation of the respiratory epithelium into the bronchial lumens.

These foci of bronchiolitis are surrounded by areas of consolidation, hemorrhage, and atelectasis.

At low power the appearance may be confused with the bacterial bronchopneumonia .

In the areas of consolidation and among the necrotizing bronchiolar epithelial lesions, cells with intranuclear inclusion bodies may be found.

In the early stages cytopathic effects are manifested by granular, slightly enlarged nuclei containing eosinophilic bodies intermixed with clumped basophilic chromatin.

The eosinophilic bodies coalesce, forming larges masses to end as a central, granular, ill-defined mass surrounded by a halo.

The second type of inclusion, which is more common and probably corresponds to a late-stage infected cell, is designated the "smudge cell".

The nucleus is rounded or ovoid, large, and completely occupied by a granular amphophilic to deeply basophilic mass.

There is no halo, and the nuclear membrane and nucleus are indistinct.

Electron microscopy of the lung demonstrates viral particles in the bronchiolar and alveolar lining cells.

 Image1  Image2  ; Image3  ; Image4 ; Image5

(Dr Yutaka Tutsumi MD)

Further reading:

 

Adenovirus isolation rates in acute flaccid paralysis patients.

 

Evaluation of Type-Specific Real-Time PCR Assays Using the

 

LightCycler and J.B.A.I.D.S. for Detection of Adenoviruses in Species HAdV-C.

 

Use of Recombinant Adenovirus Vectored Consensus IFN-α to Avert Severe Arenavirus Infection.

 

Adenovirus infection in paediatric allogeneic stem cell transplantation recipients is a major independent factor for significantly increasing the risk of treatment related mortality.

 

Occurrence of water-borne enteric viruses in two settlements based in Eastern Chad: analysis of hepatitis E virus, hepatitis A virus and human adenovirus in water sources.

 

Detection of three human adenovirus species in adults with acute respiratory infection in China.

 

Adenovirus-36 Seropositivity Enhances Effects of Nutritional Intervention on Obesity, Bright Liver, and Insulin Resistance.


 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 

 


 

 

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