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Endocrine Pathology Online

Pathology of Adrenal Cortical Adenoma Producing Conn's Syndrome

Dr Sampurna Roy MD       




Adrenal cortical adenomas which secrete aldosterone are said to be more pleomorphic and more commonly associated with nodular hyperplasia in the adjacent adrenal cortex than those producing glucocorticoides.   

Further, there may be spironolactone bodies in the adjacent cortex relating to preoperative diuretic therapy.

In practice, determination of the secretory product is not required of histopathologists since it will have been indicated from preoperative biochemical results.

It is worth remembering that in the differential diagnosis of adrenal cortical tumours from other clear cell tumours (such as renal cell carcinoma) the mitochondrial tubular cristae seen in glucocorticoid secreting cells and said to identify steroid secreting tumours are not seen in aldosterone secreting cells which have unremarkable lamellar cristae.

Visit: Adrenal Cortical Adenocarcinoma ; Adrenal Phaeochromocytoma


Further reading

Images of adrenal cortical adenoma

Spironolactone bodies in an adrenal adenoma.

A case of primary aldosteronism associated with spironolactone inclusions (author's transl).

Spironolactone bodies in aldosteronomas and in the attached adrenals. Enzyme histochemical study of 19 cases of primary aldosteronism and a case of aldosteronism due to bilateral diffuse hyperplasia of the zona glomerulosa.

[Spironolactone bodies. Light and electron microscope study apropos of 4 cases of adrenal adenomas with primary hyperaldosteronism].

Clinical review: Adrenocortical carcinoma: clinical update.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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