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Pathology of Arenavirus

(Arenaviridae)

 Dr Sampurna Roy MD        

 

                                                                                                                      

 

The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted disease in humans.

Arenaviruses are round, oval , or pleomorphic with a range in size between 100 to 130 nm.

They are enveloped particles, and the envelope contains club-shaped projections at its surface.

Electron-dense granules are found in variable numbers in the interior of the virions.

The granules are 20 to 25 nm in diameter and represent host ribosomes.

The sandlike granules gave the name to this group of viruses (arena, Latin for 'sand').

The genome of arenaviruses consists of four pieces of single-stranded RNA and several small pieces of RNA, some of which may be of host origin.

Rodents are the natural host of arenaviruses, and humans are accidentally infected when they come into contact with infected urine.

Person-to-person spread is unusual except for lassa virus .

The arenaviruses are divided into two groups: the New World or Tacaribe complex and the Old World or LCM/Lassa complex.

The relevant members of the Arenaviridae family are  lymphocytic choriomeningitis viruslassa  virus ,Junin virus (Argentine hemorrhagic fever) ,Machupo virus (Bolivian hemorrhagic fever), Guanarito virus (Venezuelan hemorrhagic fever), Sabia (Brazilian hemorrhagic fever).

 

Further reading:

Pathogenesis of arenavirus hemorrhagic fevers.

Arenavirus-mediated liver pathology

Pathological and virological features of arenavirus disease

Morphology and morphogenesis of arenaviruses

Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia

Principal host relationships and evolutionary history of the North Americanarena viruses.

Phylogeny and evolution of old world arenaviruses.

Preliminary study on potential circulation of arenaviruses in the rodent population of Nakhon Pathom Province, Thailand and their medical importance in an evoluting environment.

Genetic variation among Lassa and Lassa-related arenaviruses analysed by T1-oligonucleotide mapping.

Serological and biological evidence that Lassa-complex arenaviruses are widely distributed in Africa.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 


 

 

 

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