Have you heard of CAR?
It is not what you think.
retinopathy (CAR) is a rare,
syndromes: Clinical manifestations due
to indirect and remote effects produced by tumor metabolites or other
It is usually associated with small-cell carcinoma of
Cases have been reported with
various systemic malignant tumours.
autoantibodies are found against the photoreceptor protein recoverin.
They cause apoptotic death of retinal photoreceptor cells.
clinical presentation is rapid, progressive loss of vision and retinal
degeneration that occur in association with cancer without
direct invasion or metastasis of cancer to the retina.
Other features : Concentric
visual field defects, paracentral and
mid-peripheral scotomas, night blindness, loss of colour vision,
photosensitivity and pathological electroretinogram. There is also
evidence of uveitis.
One should be
aware of the
signs and symptoms
related to CAR as
they can be the first manifestations of a hidden malignant tumour.
Cancer associated retinopathy (CAR). Two
clinical cases and review of the literature
Recoverin, a photoreceptor-specific
calcium-binding protein, is expressed by the tumor of a patient with