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Pulmonary Pathology Online

Pathology of Central Carcinoid Tumour

Dr Sampurna Roy MD   

 

                                                                                                                      

 

 

Central carcinoid tumour is the most common type and usually presents as a slow-growing, solitary,  polypoid mass, less than 3 to 4 cm in diameter, within a major bronchus. 

They may infiltrate the bronchial wall and extend to the surrounding parenchyma and even reach the pleura or myocardium.

Microscopically, they are covered by bronchial epithelium and are composed of uniform small, round to polygonal cells arrayed in well-defined nests or cords separated by thin fibrovascular septa ( "Zellballen" ).

Other growth patterns include serpiginous cords or formation of small, rosette-like microacinar structure.

Cytologically, the tumor cells contain abundant lightly eosinophilic, granular cytoplasm with central nuclei.

The nuclei usually display a scattered, coarse ("salt-and-pepper" stippling of chromatin and an occasional nucleolus.

Mitotic figures are absent or rarely seen.

Unusual variants are with oncocytic cytoplasm (oncocytic carcinoid), with melanin pigment (pigmented carcinoid) and carcinoid with metaplastic bone formation, gland formation and abundant production of stromal mucins.

A variant composed predominantly of spindle cells arranged in fascicular pattern resembling sarcoma (usually peripheral type).

Histochemically, they are argentaffin-negative and argyrophil-positive.

Immunohistochemical stains show positive reactivity for broad-spectrum and low molecular weight cytokeratin, chromogranin, synaptophysin, neuro-specific enolase, serotonin, bombesin etc.

Electron microscopy demonstrates dense-core neurosecretory granules.

Oncocytic carcinoid is a variant of carcinoid tumor in which the tumour cells have an abundant, granular acidophilic cytoplasm.

 

Their behavior is similar to that of central carcinoid.

Further reading:

Cytopathology of oncocytic carcinoid tumor of the lung mimicking granular cell tumor. A case report.

Pigmented pulmonary carcinoid tumor. An immunohistochemical and ultrastructural study.

Oncocytic carcinoid of the lung.

The histological spectrum of bronchial carcinoid tumours.

Pulmonary oncocytic carcinoid--a case report .

Bronchial carcinoid tumors of the thorax: spectrum of radiologic findings.

Video-assisted thoracic surgery (VATS) lobectomy for typical bronchopulmonary carcinoid tumors. 

Bronchial carcinoids. Our experience with 35 cases

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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