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Pathology of Chalazion  

Dr Sampurna Roy MD         


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Syn: Meibomian gland Lipogranuloma       

Microscopic Image of Chalazion

Chalazion is a very common localized lipogranulomatous inflammatory lesion of the sebaceous gland of the eyelid, most often of the meibomian gland.

It usually occurs spontaneously due to noninfectious obstruction of sebaceous gland ducts.

Chalazion is characterized by chronic foreign-body, granulomatous inflammation.

The inflammation is centered around the meibomian glands (deep chalazion) or Zeis sebaceous glands (superficial chalazion).

The lesion presents as a slow growing, painless swelling in the eyelid.

Histologically there are multiple foci of of granulomatous inflammation. 

Small globule of fat may be noted in the center of some of the granulomas.


Further reading:


Pathology of eyelid tumors

A Comparison of Intralesional Triamcinolone Acetonide Injection for Primary Chalazion in Children and Adults

Diseases of the Meibomian Glands


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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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