Custom Search



Pathology of Chondroblastoma

Dr Sampurna Roy MD   




(1) First described by Ewing in 1928, chondroblastomas were originally named "epiphyseal chondroblastomatous giant cell tumors of the proximal humerus" by Codman in 1931. These tumours are often still termed Codman tumours.


(2) In 1942 Jaffe and Lichenstein suggested that the lesion was a specific type of tumour, distinct from giant cell tumour, and proposed the name "benign chondroblastoma".


(3) It is a rare benign tumour  that accounts for 1% of all primary bone neoplasms. Most patients are between 10 and 25 years of age at diagnosis with  a 2:1 male predominance.


(4) These lesions typically originate from chondroblasts within the epiphyses of long bones, and are most common in the proximal humerus, distal femur, or proximal tibia. Chondroblastoma occurring outside of the epiphyses of long bones is rare, with lesions of the craniofacial skeleton accounting for 6.6 to 7.1% of all cases


(5) The radiological feature of chondroblastoma is typically a lytic lesion arising in the epiphysis with an eccentric location, mostly without periosteal reaction.



(6) Microscopically, it is a highly cellular tumor  composed of uniform round to polygonal cells with well-defined cytoplasmic borders, round to ovoid nuclei, predominantly growing in cellular sheets.

There are scattered multinucleated osteoclastic giant cells arranged either singly or in groups. Pericellular "chicken wire-like" calcifications are identified pathognomonic of chondroblastoma.

"The 3 important histopathological features of chondroblastoma are mononuclear cells (chondroblasts), osteoclastic-like giant cells, and a chondromyxoid stroma surrounding neoplastic cells"


(7) Chondroblastoma must be differentiated from other giant cell tumors. The osteoclastic-like giant cells seen in chondroblastomas can have striking histological similarities to giant cell reparative granulomas, aneurysmal bone cysts, giant cell tumors, and chondromyxoid fibromas.


(8) Though normally benign, histologically aggressive forms of the disease can also occur, with associated high recurrence rates and occasional lung metastases.


Further reading:


Massive Chondroblastoma in the Proximal Humerus Simulating Malignant Bone Tumors. Case Reports in Orthopedics. 2013;2013:673576


Chondroblastoma of the Knee Treated with Resection and Osteochondral Allograft Reconstruction


Chondroblastoma in the long bone diaphysis: a report of two cases with literature review


Chondroblastoma of the femoral head: management and outcome


Chondroblastoma of the Temporal Bone: A Case Series, Review, and Suggested Management Strategy


Chondroblastoma of the Medial Cuneiform Bone in a 32-Year-Old Woman





Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)










Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen





Privacy Policy  

Advertising Policy

Copyright 2018