Pathology of Condyloma Acuminatum

Dr Sampurna Roy MD     

These are usually sexually transmitted lesions.

Clinical presentation:  The appearance ranges from a 5mm papule to large fleshy tumour mass involving anogenital region.

Microscopic features:

Hyperkeratosis, acanthosis, papillomatosis together with superficial koilocytosis and hypergranulosis.

Following treatment with Podophyllin the histological changes include:

- Pallor of epidermis
- Numerous degenerate keratinocytes in the lower half of the epidermis
- Marked increase in number of mitotic figures in the lower epidermis.

Differential diagnosis includes: Bowen's disease ;  Bowenoid papulosis and seborrheic keratosis .

Read related posts:  Verruca vulgaris; Palmoplantar wart; Verruca plana ; Epidermodysplasia verruciformis

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