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Pathology of Condyloma Acuminatum

Dr Sampurna Roy MD     




Condyloma acuminatum occurs on the anogenital mucous membrane and is associated with HPV  (HPV6 and HPV 11 are most commonly identified). 

These are usually sexually transmitted lesions.

Clinical presentation:  The appearance ranges from a 5mm papule to large fleshy tumour mass involving anogenital region.

Microscopic features:

Hyperkeratosis, acanthosis, papillomatosis together with superficial koilocytosis and hypergranulosis.

Following treatment with Podophyllin the histological changes include:

- Pallor of epidermis
- Numerous degenerate keratinocytes in the lower half of the epidermis
- Marked increase in number of mitotic figures in the lower epidermis.

Differential diagnosis includes:
Bowen's disease Bowenoid papulosis and seborrheic keratosis .

Read related posts:  Verruca vulgaris; Palmoplantar wart; Verruca plana ; Epidermodysplasia verruciformis

Further reading:

Condylomata acuminata and human genital cancer

Human papilloma virus-16 causing giant condyloma acuminata

Pigmented condyloma acuminatum

Cytology of gynecologic condyloma acuminatum.

Squamous cell carcinoma arising in a giant condyloma acuminatum (Buschke-Lowenstein tumour).

Condyloma acuminatum and condyloma-like lesions of the oral cavity: a study of 11 cases with an intraductal component.

Virus-induced anorectal diseases. Condylomata acuminata and herpes simplex.

A Clinical and Pathological Overview of Vulvar Condyloma Acuminatum, Intraepithelial Neoplasia and Squamous Cell Carcinoma

Refractory condylomata acuminata: a controlled clinical trial of carbon dioxide laser versus conventional surgical treatment.






Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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