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Pathology of Gingival Granular Cell Tumour of Newborn (Congenital Epulis)

Dr Sampurna Roy MD

Pathology Quiz Case 10: Case history and images:

Diagnosis : Congenital Gingival Granular Cell Tumour (Congenital Epulis)

 

                                                                                                                      

 

Syn: Neumann's tumor

Congenital gingival granular cell tumours are rare benign tumours which is apparent at birth.

The histogenesis is still uncertain, but several theories, including origin from epithelial, undifferentiated mesenchymal cells, pericytes, fibroblasts, smooth muscle cells, and nerve-related cells have been proposed.

Site: Alveolar ridge of the maxilla in newborns .

Sex: Striking predilection for female infants suggests the presence of an endogenous hormonal stimulus in utero.

Microscopic features: 

Like adult granular cell tumour, this lesion is composed of polygonal cells with abundant granular cytoplasm and small eccentric nuclei with occasional small nucleoli.

There is a prominent vascular stroma with perivascular lymphocytes and histiocytes.

Entrapped non-neoplastic odontogenic epithelium may be present in some cases.

There is no pseudoepitheliomatous hyperplasia of the overlying squamous mucosa and no nerve bundles are seen within these lesions.

The tumour is negative when immunostained with S100 protein, in contrast to adult granular cell tumours.

Visit related post: Pathology of Granular Cell Tumour

 

Differential diagnosis:

Teratoma, leiomyoma, congenital dermoid cyst, congenital fibrosarcoma and congenital lipoma.

 

Further reading:

Congenital granular cell epulis.

A case of congenital granular cell epulis in the maxillary anterior ridge: a study of cell proliferation using immunohistological staining.

Congenital granular cell tumour of the newborn: A case report and literature review.

Congenital granular cell lesion: clinical, microscopic and immunohistochemical aspects in a case of multiple lesions.

Congenital epulis.

Gingival granular cell tumor of the newborn: a case report and review of literature.

Congenital granular cell lesion: A rare tumor of new born.

[Congenital epulis of a newborn twin--a case report].

Congenital granular cell tumor with uncommon clinical behavior.

Congenital granular cell epulis of a newborn.

Congenital granular cell lesion in newborn mandible.

Prenatal diagnosis of congenital epulis by 2D/3D ultrasound and magnetic resonance.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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