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Pathology of Cutaneous


Dr Sampurna Roy MD       


Dermatopathology Quiz Case 8

Diagnosis: Cutaneous Lymphadenoma



Cutaneous lymphadenoma is a rare tumour with distinctive histologic features.

This entity was originally described as lymphoepithelial tumour of the skin by Santa Cruz and Barr in 1987.

It was renamed cutaneous lymphadenoma in 1991.  Cutaneous lymphadenoma.

Ackerman et al considered that cutaneous lymphadenoma is a variant of trichoblastoma ("adamantinoid trichoblastoma").

Clinical presentation:
 A single, small, non-ulcerated, dome-shaped, flesh-colored,  well-circumscribed, slowly enlarging nodule.

The lesion has usually been present for many months or years.

Age and sex: Usually between 21 and 75 years without a sex predominance.

Site:  Face and scalp regions or legs.

Microscopic features:

Multiple rounded islands or nests of epithelial cells ;

Tumour lobules consist of an outer rim of palisading basaloid cells surrounding a central zone of large cells with clear cytoplasm and large vesicular cells ;

Dense infiltrate of small, mature lymphocytes within the islands ;

Tumour lobules embedded in a loose-to-dense fibrous stroma ;  

Few scattered lymphocytes in the stroma ;

Focal follicular differentiation and sometimes sebaceous differentiation;

Focal mucinosis, osteoma formation or prominent sweat gland duct component in some cases ;

Central keratinization in some lobules.


Clear epithelial cells in the lobules and the basaloid peripheral cells: Cytokeratin positive.

Lymphoid component reacted with common leukocyte antigen (CLA) and  T-cell markers (UCHL-1, CD3).  

Some CD30+ large clear cells may be present. 

Many large epithelial cells in the lobules and some dendritic cells in the stroma : S-100 positive.

Differential diagnosis:

Clear cell syringoma ;  clear cell basal cell carcinoma ; lymphoepithelioma-like carcinoma of skin.

Cutaneous lymphadenoma does not tend to recur after surgical excision.

Further reading:

Cutaneous lymphadenoma.

Mohs micrographic surgery for cutaneous lymphadenoma.

Cutaneous lymphadenoma: a case report and immunohistochemical study.

A cutaneous adnexal neoplasm with features of adamantinoid trichoblastoma (lymphadenoma) in the benign component and lymphoepithelial-like carcinoma in the malignant component: a possible case of malignant transformation of a rare trichoblastoma variant.

Cutaneous lymphadenoma: a rare clinicopathological entity.

Cutaneous lymphadenoma.

Cutaneous lymphadenoma.

Lymphoepithelial tumor of the skin (abstr.). J Cutan Pathol 1987; 14: 345.





Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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