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Pathology of Adenoid Cystic Carcinoma of the External Ear

Dr Sampurna Roy MD      

 

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Adenoid cystic carcinoma of the external auditory canal (EAC) is a very rare malignant tumour and its diagnosis is frequently missed because of the superficial nature of biopsies.

Adenoid cystic carcinomas of the ceruminous gland are morphologically similar to the more commonly encountered salivary gland tumors.

As do their more common salivary gland analogs, adenoid cystic carcinomas of the ceruminous glands have a propensity for perineural growth.

This tendency accounts for most cases of intracranial involvement by adenoid cystic carcinomas of the ceruminous gland, as the neoplasm grows along the nerves and by direct extension involves the central nervous system.

It has been proposed for salivary gland neoplasms that the propensity for perineural involvement is related to the expression of neural cell adhesion molecules by the neoplastic tumour cells.

Treatment of adenoid cystic carcinomas of the ceruminous gland  involves complete surgical resection with clear surgical margins.

This objective can be difficult to achieve because of the perineural involvement commonly encountered in these neoplasms.

In the ceruminous gland, cytokeratin shows diffuse positive staining, while myoepithelial cells are stained for smooth muscle actin, desmin, S-100 protein and vimentin.

Adenoid cystic carcinoma in external auditory canal grows slowly, so patients can live with the tumour for a long time. 

It is necessary to do both aggressive surgery and postoperative irradiation.

The long term follow-up indicates that the tumour has a poor prognosis.

Cutaneous adenoid cystic carcinoma;

Pulmonary adenoid cystic carcinoma.

 

Further reading:

Adenoid cystic carcinoma of external auditory canal: 8 cases report.

Adenoid Cystic Carcinoma- A rare Differential Diagnosis for a mass in the External Auditory Canal.

Adenoid cystic carcinoma of the external auditory canal.

Six cases of adenoid cystic carcinoma in external auditory canal.

Adenoid cystic carcinoma of ceruminous gland: a case report.

Adenoid cystic carcinoma of external auditory canal: a report of 7 cases.

10 Microscopic Features of Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome)

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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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