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Pathology of Myospherulosis of the Ear

Dr Sampurna Roy MD    


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Myospherulosis is a chronic-inflammatory lesion that is most commonly iatrogenic of origin. 

It is caused by the implantation during surgery of mineral oil- or petroleum-based products into various tissues.

The condition results from the action of lipid substances on extravasated erythrocytes.

Histologically, ear biopsy may show cystic tissue spaces lined by histiocytes and foreign-body giant cells in a fibrous stroma.

In the tissue spaces, scattered debris and sac-like structures containing round spherules of aggregated erythrocytes are found. In addition, erosion of adjacent bone matrix may be seen.


Further reading

Chronic otorrhea caused by myospherulosis in the middle ear after tympanoplasty.

Myospherulosis of the middle ear -- a rare differential diagnosis of cholesteatoma .

Spherulocytosis (myospherulosis) of the paranasal sinuses .

Myospherulosis in the operated temporal bone.

Myospherulosis of the paranasal sinuses, nose and middle ear. A possible iatrogenic disease.

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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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