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Fibrohistiocytic Tumours

Pathology of Epithelioid Fibrous Histiocytoma


Dr Sampurna Roy MD   





In 1989 Jones et al described a previously unknown variant of fibrous histiocytoma. They called the lesion "epithelioid cell histiocytoma" Epithelioid cell histiocytoma: a new entity.

Salient features of the tumour:

- Epithelioid Fibrous Histiocytoma presents as an exophytic nodule.

- It is a dermal tumour that can mimic melanocytic, vascular, epithelial, or other histiocytic lesions.

-  The lesion is usually located on the extremities in adults.

- Microscopically, it is a polypoid lesion with epidermal collarette.

 Microscopic images of Epithelioid Fibrous Histiocytoma

- Most striking feature is the presence of sheets of angulated epithelioid with abundant eosinophilic cytoplasm (resemble Spitz nevus).

Alves JVP, Matos DM, Barreiros HF, Bártolo EAFLF. Variants of dermatofibroma - a histopathological study . Anais Brasileiros de Dermatologia. 2014;89(3):472-477. doi:10.1590/abd1806-4841.20142629.

- No junctional component or theques noted.

- Giant cells, xanthoma cells and vascular spaces may be present.

- S100 and HMB45- negative, Factor XIIIa - positive, Vimentin- positive, CD31,CD34- negative in the tumour cells but highlight the blood vessels.


Further reading:

Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.  

Epithelioid cell histiocytoma - histogenetic and kinetics analysis of dermal microvascular unit dendritic cell subpopulations.

Epithelioid benign fibrous histiocytoma of skin: clinico-pathological analysis of 20 cases of a poorly known variant.

Epithelioid cell histiocytoma. A report of 10 cases including a new cellular variant.

Epithelioid cell histiocytoma: a simulant of vascular and melanocytic neoplasms.

Cellular 'neurothekeoma': an epithelioid variant of dermatofibroma?






Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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