Pathology of Epidermodysplasia Verruciformis

Dr Sampurna Roy MD                        2022

Epidermodysplasia verruciformis (EV) was initially described by Lewandowski and Lutz in 1922.

Epidermodysplasia verruciformis (EV) is a rare, autosomal recessive inherited skin disorder in which there is widespread and persistent infection by multiple subtypes of human papilloma virus. The patients have high risk of cancer.

Epidermodysplasia Verruciformis usually occurs in infancy and childhood.

Clinically the lesion presents as flat or papular wart, scaly macule or hypopigmented tinea versicolor-like lesions.

These are usually located on the face, neck or upper trunk.

Numerous HPV subtypes are associated with Epidermodysplasia Verruciformis.

HPV 5 and 8 are known to have highest oncogenic potential.

Some lesions are similar to plane warts where as others resemble seborrheic keratosis.

Almost half of all patients with Epidermodysplasia verruciformis will develop cutaneous malignancies like Bowen's type carcinoma-in situ and invasive squamous cell carcinoma.

These lesions usually occur on sun exposed areas in the fourth of fifth decade of life. 

Epidermodysplasia Verruciformis in a young man with HIV since birth - Case report . Anais Brasileiros de Dermatologia. 2013;88(6 Suppl 1):190-192. doi:10.1590/abd1806-4841.20132328.

Acquired epidermodysplasia verruciformis in a renal transplant recipient - Case report . Anais Brasileiros de Dermatologia. 2014;89(1):144-146. doi:10.1590/abd1806-4841.20142803. 10.1590/abd1806-4841.20142803

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