chronicum migrans is a skin lesion of the tick borne spirochetosis,
lesion, (measures 5-20 cm in diameter) develops within 3 months of the
multiple in some cases.
Secondary erythema migrans result from
hematogenous spread of the organism.
disappear from the lesion after treatment with antibiotics (doxycycline
and synthetic penicillin).
Histologically, there is a superficial and deep perivascular and
interstitial infiltrate of lymphocytes.
In some cases plasma cells and eosinophils are present. Eosinophils may be present at the site of
tick bite. A few neutrophils may also be noted.
: Warthin-Starry silver stain - In some specimens spirochetes
are identified in the papillary dermis at the dermoepidermal junction.
be confirmed by using an indirect immunofluorescence or
may also be identified in formalin-fixed paraffin-embedded lesions by
polymerase chain reaction method.
Visit: Lyme Disease (Lyme Borreliosis)
Acrodermatitis chronica atrophicans