|
Riedel's thyroiditis and fibrous variant of Hashimoto's thyroiditis: a
clinicopathological and immunohistochemical study.J
Endocrinol Invest. 2003 May;26(5):444-9.
The aim of
this study was to analyze and compare clinico pathological aspects of
Riedel's thyroiditis (RT) and the fibrous variant of Hashimoto's
thyroiditis (HTFV), and to show their immunohistochemical features. We
reviewed 6 cases of HTFV and 4 cases of RT. Compared to RT, HTFV
patients had hypothyroidism, no pressure symptoms, and frequently
diagnostic fine-needle aspiration biopsy (FNAB) cytology. At
histology, invasion of surrounding tissues and presence of occlusive
phlebitis distinguished RT from HTFV. At immunohistochemistry, RT--compared
to HTVF--was characterized by: 1) a more abundant fibrous reaction,
and granulocytic, monocytic and eosinophil infiltration; 2) few
plasma-cells, CD8+ T- and B-lymphocytes. The results of our study add
further evidence regarding the separation of RT and HTFV in their
peculiar clinical, laboratory, cyto-histological and
immunohistochemical aspects.
A thyroid
biopsy with histologic features of both Riedel's thyroiditis and the
fibrosing variant of Hashimoto's thyroiditis.Hum
Pathol. 1992;23(9):1072-5.
We describe a
36-year-old woman with clinical, laboratory, and histologic features
of both Riedel's thyroiditis and the fibrosing variant of Hashimoto's
thyroiditis. Features of the former included a hard, fixed thyroid
mass and extensive involvement of perithyroidal tissues by dense
fibrosis with lymphocytes, histiocytes, and plasma cells. Features
supporting Hashimoto's thyroiditis included high serum titers of
antimicrosomal and antithyroglobulin antibodies and the histologic
findings within the thyroid gland itself: dense fibrous bands dividing
the thyroid parenchyma into nodules composed of lymphoid follicles
with germinal centers, plasma cells, and oxyphilic metaplasia of
follicular epithelial cells. Although Riedel's thyroiditis and the
fibrosing variant of Hashimoto's thyroiditis were once considered
morphologic variants of the same disease, since the 1970s these
diseases have been considered as distinct clinicopathologic entities.
The coexistence of both diseases in a patient is rare and is probably
coincidental in this instance.
Simultaneous involvement of thyroid by Riedel's
[correction of Reidel's] disease and fibrosing Hashimoto's thyroiditis:
a case report.
Thyroid. 1998 Apr;8(4):337-41. Erratum in: Thyroid 1998
Aug;8(8):736.
We report an
unusual thyroid lesion showing histologic features of both Riedel's
[corrected] disease and fibrosing Hashimoto's thyroiditis in a
57-year-old white female. The clinical presentation was hypothyroidism
associated with a solitary firm to hard cold nodule replacing the
entire right lobe of thyroid gland. Pathological examination
demonstrated extensive replacement of the thyroid parenchyma with
dense keloidal fibrosis, intermixed well-developed lymphoid follicles,
scattered lymphocytes, and plasma cells. The fibrotic process extended
into the perithyroidal soft tissues and skeletal muscle with complete
obliteration of the thyroid capsule. These findings were consistent
with Riedel's [corrected] disease. However, the immunohistochemical
stains for B and T markers and immunoglobulin light chains showed an
immunoprofile consistent with Hashimoto's thyroiditis. This
combination of Riedel's [corrected] disease and fibrosing Hashimoto's
thyroiditis is rare and coincidental, as both represent two distinct
clinicopathological entities.
|
