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Pathology of Gastrointestinal Glomus Tumour

Dr Sampurna Roy MD


Path Quiz Case 5 - Case history and images:

Diagnosis: Gastric Glomus Tumour



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Glomus tumours have been reported in the stomach and occasionally in the intestines.

Gastrointestinal glomus tumours occur most commonly in older women.

Gastric glomus tumours usually occur in the gastric antrum of adults.

It is the second commonest site after the skin. These are mostly benign lesions.

Visit related post: Pathology of Glomus Tumour

Malignant tumours have been reported with metastases to the liver, lymph nodes, and peritoneum.

The gastric tumours typically presents with gastrointestinal bleeding.

The mucosa overlying the tumour is often ulcerated. 

In some cases the tumours are incidental findings during clinical evaluation or abdominal operation.  

The average size of the intramural nodules are 2 to 2.5 cm and are mostly located in the muscularis propria.

Pseudocapsule may form around the lesion.

Microscopic features of Gastric Glomus Tumour:  



The lack of CD117 positivity has been described as a  feature of glomus tumour of gastrointestinal origin, and this helps to distinguish glomus tumour from gastrointestinal stromal tumours.

Leukocyte common antigen and neuroendocrine markers, such as synaptophysin and chromogranin, are negative.

Smooth muscle actin and muscle-specific antigen, are positive.

Differential diagnosis: Epithelioid stromal tumour ; Carcinoid ; Malignant lymphoma.


Further reading:

Clinicopathological features of gastric glomus tumor

Gastric glomus tumor: A case report

Glomus tumor in the stomach: Computed tomography and endoscopic ultrasound findings

Glomus Tumor of the Stomach: A Rare Cause of Upper Gastrointestinal Bleeding

Glomus Tumor of the Stomach Simulating a Gastrointestinal Stromal Tumor: A Case Report and Review of Literature

Glomus Tumor of the Stomach: A Clinicopathologic Analysis of 10 Cases and Review of the Literature

Glomus Tumor of the Stomach: Depiction by Multidetector CT and Three-Dimensional Volume Rendering Imaging

Malignant Glomus Tumor (Glomangiosarcoma) of Intestinal Ileum: A Rare Case Report

Gastric glomus tumor

Glomus tumor of the duodenum: a case report

Glomus tumor of the stomach: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration.  

Glomus tumour of the stomach. A case report

Gastrointestinal Glomus Tumors. A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 32 Cases.

Diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle aspiration biopsy. A case report with cytologic, histologic and immuno-histochemical studies

Pathologic quiz case: an incidental gastric massin a 71-year old man who presented with pancreatic pseudocyst. Gastric glomus tumor.

A case of glomangioma of the stomach.

Hemorrhagic gastric glomus tumor mimicks a leiomyosarcoma on both transabdominal and endoscopic ultrasonography: case report.

Multiple glomus tumors of the stomach with intravascular spread.

Locally infiltrative glomus tumors and glomangiosarcomas. A clinical, ultrastructural, and immunohistochemical study.

A case of glomus tumor of the stomach, including a review of the literature of 52 reported cases in Japan.


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Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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