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Pathology of Glanders

Dr Sampurna Roy MD

 

                                                                                                                      

 

 

Glanders is an infection of equine species and rarely of humans.

 

The cause is Burkholderia mallei , a small, gram-negative, nonmotile bacillus.

 

Visit: Pathology of Melioidosis

It may be acute and severe or protracted and wasting.

The causative agent of glanders, Burkholderia mallei, is highly contagious and leads to chronic disease in horses whereas in donkeys and mules the disease is acute and often fatal. 

Occurrence of the disease leads to international trading restrictions and infected animals immediately should be culled and safely disposed off.

In humans Burkholderia mallei infection results in a severe clinical course, and is fatal without appropriate therapy.

Its pathogenicity makes Burkholderia mallei a potential biological agent that may be used in bioterroristic attacks.

Although uncommon, glanders remain endemic in South America, Asia, and Africa.

In addition there have been rare infections of laboratory workers in the United States and Canada.

The natural reservoir is equines and transmission to human is by contact through broken skin or by inhalation of contaminated aerosols.

Glanders may also be transmitted from person to person.

The acute disease is characterized by papule at the site of inoculation, followed by bacteremia with severe prostration, fever, vomiting, and generalized pain.

The bacilli drain from the primary papule through lymphatics to regional lymph nodes and then to the blood stream.

Abscesses may form along the draining lymphatics, in the regional nodes and in many organs throughout the body, including the lung, liver, spleen, muscle, joints, and especially the subcutaneous tissues.

The abscesses are composed of a central zone of neutrophils surrounded by a granulomatous perimeter.

Patients with the chronic form of glanders show a  low-grade fever, draining abscesses of skin, lymphadenopathy, and hepatospenomegaly.

The lesions begin as abscesses and evolve to granulomas, mimicking tuberculosis.

In its acute form, glanders is almost always fatal, and in the chronic form mortality is more than 50%.

Some success in treatment has been achieved with sulfonamides.

The lesions are not pathognomonic, and the diagnosis depends on the isolation of Burkholderia mallei or the detection of compliment-fixing antibodies.

Although Burkholderia mallei may be cultured from blood, sputum or pus, its high potential for causing laboratory-acquired infection requires strict containment.   

Further reading:

Glanders--a comprehensive review.

Detection and differentiation of Burkholderia pseudomallei, Burkholderia mallei and Burkholderia thailandensis by multiplex PCR.

Molecular-genetic approaches to diagnosis and intraspecific typing of causative agents of glanders and melioidosis.

Identification of the causative agents of glanders and melioidosis by polymerase chain reaction.

Glanders--an eradicable disease--or a threat?

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 


 

 

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