DermPath-India

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 Dr Sampurna Roy MD

          

http://www.histopathology-india.net/dermpath.htm

                             HISTOPATHOLOGY INDIA.COM

            Neurofibroma

          Dr Sampurna Roy MD

 
Web www.histopathology-india.net
      Gastrointestinal Stromal Tumour

          

http://www.histopathology-india.net/SoftTissuePath.htm

 
June 2007
Normal Anatomy of the Nerve

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Myxoid Tumours of Soft Tissue

Classification of Soft Tissue Tumour

Gross examination of soft tissue specimen          

A practical approach to histopathological reporting of soft tissue tumours

Grading of soft tissue tumours

Lipomatous tumours

Neural tumours

Myogenic tumours

Fibroblastic/Myofibroblastic tumours

Myofibroblastic tumours

Fibrohistiocytic tumours

ChondroOsseous tumours

Soft TissueTumours of Uncertain Differentiation               

Notochordal Tumour - Chordoma

Extra-adrenal Paraganglioma

Gastrointestinal Stromal Tumour

                 

Syn: Nasal Glioma ; Glial Heterotopias.

Nasal gliomas or heterotopia are nonhereditary congenital malformations composed of heterotopic neuroglial tissue.

Encephaloceles and glial heterotopias are related tumour -like lesions. Encephaloceles are usually associated with bony defects unlike glial heterotopias.

Site:
Occur in the subcutaneous tissue (60%) or may be intranasal in location (30%).
Both external and intranasal components may be present.
Rarely may occur on the scalp, either as multiple subcutaneous nodules or as a single midline parietal nodule.

Clinical presentation:
The lesion presents as reddish blue, firm nodule on the bridge of nose, usually at birth or in early infancy.


Histopathology: Image Link: click
Unencapsulated, multilobulated lesion composed of islands of neural and fibrovascular tissue.
The neural tissue is composed of astrocytes set in a neurofibrillary stroma.
Neurons are usually absent.
Old cases show prominent stromal sclerosis.
Some cases show cystic change and rarely focal calcification.

Immunohistochemistry:
Glial fibrillary acidic protein (GFAP),  S-100 protein  and  vimentin : Positive
The nodules do not contain meningeal covering (EMA  is negative).

Complete surgical excision of nasal glial heterotopias is curative

                 

Abstracts:

Nasal glial heterotopia: embryological and clinical approaches.Rev Stomatol Chir Maxillofac. 2006 ;107(1):44-9.

Both nasal cerebral heterotopia and encephalocele in the same patient.Cleft Palate Craniofac J. 2006 Jan;43(1):112-6.

Heterotopic neural nodules of the scalp.Plast Reconstr Surg. 2005 Feb;115(2):376-82.

Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature.Ann Diagn Pathol. 2003 Dec;7(6):354-9.

Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases.Clin Neuropathol. 2002 ;21(2):66-71.

Glial heterotopia in the subcutaneous tissue overlying T-12.J Cutan Pathol. 1999 Nov;26(10):523-7.

Nasal glioma: an immunohistochemical and ultrastructural study.Pathol Int. 1995 May;45(5):393-8. Your Banner
PULMONARY PATHOLOGY:

Congenital Cystic Adenomatoid  Malformation ; Acute Respiratory Distress Syndrome  ;Sarcoidosis ;Bronchiolitis ; Emphysema ; Bronchial Asthma ; Chronic Bronchitis ; Pulmonary Alveolar Proteinosis ; Lipid Pneumonia ; Pulmonary Hypertension ;Pulmonary edema ;Pulmonary Infection ; Pneumococcal Pneumonia ; Haemophilus influenza Infection; Klebsiella Pneumoniae ; Mycoplasma Pneumonia ; Pneumocystis Pneumonia ; Legionellosis ; Localized Fibrous Tumour of the Pleura ; Biphasic Epithelial/Mesenchymal Lung Tumours ; Pulmonary Carcinosarcoma ;Pulmonary Blastoma ; Large Cell Neuroendocrine tumour;

INFECTIOUS DISEASE ONLINE:   A:

Acrodermatitis chronica atrophicans ; Actinomycosis ; Adenovirus ; African Histoplasmosis  ;  AIDS: Cutaneous lesion associated with AIDS ;  AIDS related malignant tumours ; African Trypanosomiasis ; Alphaviruses causing Encephalitis ; Amebic Meningoencephalitis ; American Trypanosomiasis ;  Amoebiasis  ; Ancylostomiasis ; Angiostrongyliasis ; Anisakiasis;  Anthrax Infection ; Arenavirus ; Argentine hemorrhagic fever ; Arthropod-borne viral encephalitis ; Ascariasis ; Aspergillosis ;Atypical Mycobacterial Infection ;Avian Influenza  ;

Reactive and hamartomatous lesions:

Traumatic neuroma

Morton's neuroma

Digital Pacinian neuroma

Nerve Sheath Ganglion

Fibrolipomatous hamartoma of nerve

Benign tumours:

Solitary circumscribed neuroma
(palisaded encapsulated neuroma)

Schwannoma (neurilemmoma)
and variants                          

Neurofibroma and variants 

Perineurioma   

Dermal nerve sheath myxoma
(neurothekeoma)

Cellular neurothekeoma

Granular cell tumour

              
Malignant tumour:

Malignant peripheral nerve sheath tumour
  


Neuroendocrine Carcinoma:

Merkel cell (neuroendocrine) carcinoma

Malignant primitive neuroectodermal tumour   

Miscellaneous neuroectodermal tumours presenting in soft tissue

Subcutaneous Myxopapillary Ependymoma  

Heterotopic Glial Nodule

Heterotopic Meningeal Lesions

MESOTHELIOMA-ONLINE           

         http://www.histopathology-india.net/MesoOnline.htm

 

Cardiac Path Online;

PRIMARY TUMOURS OF THE HEART

REPORTING OF CARDIAC TUMOURS

CARDIAC MYXOMA

CARDIAC RHABDOMYOMA

PAPILLARY FIBROELASTOMA

CARDIAC FIBROMA

CARDIAC LIPOMA

CARDIAC HEMANGIOMA

CARDIAC TERATOMA

MESOTHELIOMA OF ATRIOVENTRICULAR NODE

PURKINJE CELL TUMOUR

CARDIAC PARAGANGLIOMA

MALIGNANT TUMOURS OF THE HEART

CARDIAC LYMPHOMA