Pathology of Heterotopic Glial Nodules
Syn: Nasal Glioma ; Glial
Nasal gliomas or heterotopia are nonhereditary congenital malformations composed of heterotopic neuroglial tissue.
Encephaloceles and glial heterotopias are related tumour-like lesions.
usually associated with bony defects unlike glial heterotopias.
Occur in the subcutaneous tissue (60%) or may be intranasal in location (30%).
Both external and intranasal components may be present.
Rarely may occur on the scalp, either as multiple subcutaneous nodules or as
a single midline parietal nodule.
The lesion presents as reddish blue, firm nodule on the bridge of nose, usually at birth or in early infancy.
Unencapsulated, multilobulated lesion composed of islands of neural and fibrovascular tissue.
The neural tissue is composed of astrocytes set in a neurofibrillary stroma.
Neurons are usually absent.
Old cases show prominent stromal sclerosis.
Some cases show cystic change and rarely focal calcification.
fibrillary acidic protein (GFAP), S-100 protein and vimentin : Positive
Complete surgical excision of nasal glial heterotopias is curative
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