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Pathology of Hepatoblastoma

Dr Sampurna Roy MD                        June 2015

Children under 5 years of age are usually affected.

The tumor is rarely present at birth and an upper abdominal mass or an enlarging abdomen is the most common clinical presentation.

The right lobe of the liver is involved in 60-65% of cases.

The neoplasm is usually a single well-circumscribed mass confined to one lobe of the liver.

Hepatic cirrhosis is not associated with the tumor.

Histological sub-types include fetal, embryonal, macrotrabecular and small-cell undifferentiated (anaplastic), as well as epithelial/ mesenchymal (mixed).

Prognostically, complete resection  (stage 1) seems to offer the best chance of survival.

 

                                          
Further reading:

The emerging family of hepatoblastoma tumours: from ontogenesis to oncogenesis.

Hepatoblastoma: assessment of criteria for histologic classification.

Clinicopathological and immunohistochemical study of hepatoblastoma.

Neuroendocrine differentiation in hepatoblastoma. An immunohistochemical investigation.

Hepatoblastoma: an immunohistochemical and ultrastructural study.

Hepatoblastoma. Attempt at characterization of histologic subtypes.

Protocol for the examination of specimens from pediatric patients with hepatoblastoma.

Predictive value of staging systems in hepatoblastoma.

Cytologic diagnosis of small cell anaplastic hepatoblastoma: a case report.

Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma.

Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study.

Fine needle aspiration cytology of hepatoblastoma. Recognition of subtypes on cytomorphology.

Hepatoblastoma--evolution of management and outcome and significance of histology of the resected tumor. A 31-year experience with 40 cases.

Hepatoblastoma in a 15-month-old male: cytomorphology, electron microscopy, and differential diagnosis.

Hepatoblastoma: cytomorphologic characteristics in serious cavity fluids.

Surgical view of the treatment of patients with hepatoblastoma: results from the first prospective trial of the International Society of Pediatric Oncology Liver Tumor Study Group.

Hepatic tumors in children.

Pediatric liver neoplasms: a radiologic-pathologic correlation.

Immunohistochemical evaluation of hepatoblastomas with use of the hepatocyte-specific marker, hepatocyte paraffin 1, and the polyclonal anti-carcinoembryonic antigen.

An approach to handling pediatric liver tumors.

Hepatoblastoma. Report of a case with cytologic, histologic and ultrastructural findings.  

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 

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