Pathology of Hepatoblastoma
Dr Sampurna Roy MD June 2015
Children under 5 years of age are usually affected.
The tumor is rarely present at birth and an upper abdominal mass or an enlarging abdomen is the most common clinical presentation.
The right lobe of the liver is involved in 60-65% of cases.
The neoplasm is usually a single well-circumscribed mass confined to one lobe of the liver.
Hepatic cirrhosis is not associated with the tumor.
Histological sub-types include fetal, embryonal, macrotrabecular and small-cell undifferentiated (anaplastic), as well as epithelial/ mesenchymal (mixed).
Prognostically, complete resection (stage 1) seems to offer the best chance of survival.
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