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Pathology of Isolated Pulmonary Capillaritis

Dr Sampurna Roy MD 

 

                                                                                                                      

 

 

Pulmonary capillaritis is defined as a histopathologic pattern of alveolar wall inflammation that leads to the disruption of the integrity of alveolar-capillary basement membranes and flooding of the alveoli with blood.

The clinical presentation is that of diffuse alveolar hemorrhage (DAH).

Pulmonary capillaritis is usually the consequence of an underlying immune-mediated process that is systemic in nature. Rarely, pulmonary capillaritis occurs in isolation.

It has been noted that small vessel vasculitis may be confined to the lungs and is one of the most frequent causes of pulmonary capillaritis.

The serum contains pANCA in a minority of cases and the disease may be an organ-specific form of  Microscopic Polyangiitis , just as isolated idiopathic glomerulonephritis, which is also pANCA related, may be a form of Microscopic Polyangiitis confined to the kidney.

 

Further reading:

Antineutrophil cytoplasmic autoantibody-associated alveolar capillaritis in patients presenting with pulmonary hemorrhage.

Pulmonary capillaritis in children: a review of eight cases with comparison to other alveolar hemorrhage syndromes.

Pulmonary capillaritis.

Pulmonary capillaritis.

Diffuse alveolar hemorrhage with underlying isolated, pauciimmune pulmonary capillaritis.

Pulmonary capillaritis and alveolar hemorrhage. Update on diagnosis and management.

Pulmonary capillaritis and hemorrhage in patients with systemic vasculitis.

Pulmonary capillaritis. The association with progressive irreversible airflow limitation and hyperinflation.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 


 

 

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