Syn: Poorly differentiated
Anaplastic Carcinoma ; Undifferentiated Large Cell Carcinoma.
According to some authors the existence of Large Cell Carcinoma as a definite entity has been challenged. Some consider it to be a "wastebin" category.
The tumour is composed of sheets of poorly differentiated large tumour cells.
The cells contain round to oval nuclei and prominent nucleoli.
There is marked cellular atypia and an increased mitotic activity.
The tumour shows no definite evidence of either squamous or glandular differentation.
Unlike pleomorphic carcinoma there is no evidence of any spindle cell component, atypical multinucleated and giant tumour cells.
Large cell carcinomas of the lung showing evidence of neuroendocrine differentiation is a distinctive clinicopathologic disease and should not be classified with unspecified large cell anaplastic carcinomas of the lung.
Applying specialized techniques, most cases of large cell carcinoma can be further reclassified into more informative categories that may guide molecular testing for predictive biomarkers and enable selection of more appropriate therapies.
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