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Pulmonary Pathology Online

Pathology of Lymphoepithelioma-like Carcinoma of the Lung

 Dr Sampurna Roy MD  





Lymphoepithelioma-like carcinoma (LELC), best known to occur in the nasopharynx, can arise in a variety of sites, such as the salivary gland, thymus, lung, stomach, and skin.

Primary Lymphoepithelioma-like carcinoma (LELC) of the lung is a very rare tumour and was first reported in 1987.

Lymphoepithelioma-like carcinoma of lung occurring in Asians is an EBV-associated neoplasm. 

It also appears to occur at a higher frequency in Asians than Caucasians.

There is no strong association with cigarette smoking.

It usually presents as a solitary subpleural nodule.

Primary pulmonary Lymphoepithelioma-like carcinoma (LELC) is histopathologically identical to nasopharyngeal carcinoma.

Microscopically, the tumour is characterized by poorly differentiated squamous carcinoma with prominent lymphoid stroma.

The tumour cells contain large, vesicular nuclei with prominent eosinophilic nucleoli and scanty rim of cytoplasm.

Most patients have early stage disease at presentation.

The behavior of Lymphoepithelioma-like carcinoma (LELC) of lung is highly variable, ranging from apparent curability by excision (particularly for localized disease) to highly aggressive, extensive disease at presentation.


Further reading:

Lymphoepithelioma-like carcinoma of the lung.

Lymphoepithelioma-like carcinoma of the lung: radiologic features of an uncommon primary pulmonary neoplasm.

Lymphoepithelioma-like carcinoma of the lung: case in which the patient has been followed up for 7 years postoperatively.

Primary lymphoepithelioma-like carcinoma of the lung.

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma.

Clinicopathologic features and prognosis of lymphoepithelioma-like carcinoma of the lung .

Lymphoepithelioma-like carcinoma of the lung with a better prognosis. A clinicopathologic study of 32 cases.

Primary lymphoepithelioma-like carcinoma of the lung. A clinicopathologic study of 11 cases.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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