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Pathology of Meckel's


Dr Sampurna Roy MD

GI Path Online- Home Page Pathology of Small Intestine - Home Page

August 2015


Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


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Normal histology of the small intestine for anatomic pathologists

An approach to evaluation of small intestinal biopsy.

Malabsorption syndrome

Tropical Sprue

Coeliac Disease

Enteropathy-associated T-cell lymphoma

Intestinal lymphangiectasia

Meckel's diverticulum is derived from an abnormal persistence of the proximal part of the vitelline duct.

It is situated 80cm proximal to the ileocaecal junction on the antimesenteric border.

Macroscopically, it is a small pouch or a blind segment which varies in length from less than 1cm to 8cm, and lumen diameter is greater than that of the ileum.

This is a true diverticulum containing all three layers of the bowel wall (mucosa, submucosa and muscularis propra).

Histology reveals normal small intestinal mucosa.Often heterotopic rests of gastric and colonic mucosa or pancreatic tissue may be present.


Complications of Meckel's diverticulum:

1) Inflammation 

2) Perforation, 

3) Vesiculodiverticular fistula,

4) Ulceration (peptic ulceration occurs in the ileum adjacent to the heterotopic gastric mucosa).

5) Haemorrhage (painless bleeding is common symptom in diverticulitis).

6) Intussusception 

7) Intestinal obstruction from attached bands and tumours.

8) Carcinoid tumours have been often reported.

9) Other tumours arising in Meckel's diverticulum include - adenocarcinoma, villous adenoma, leiomyoma, leiomyosarcoma, malignat melanoma.


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Normal Histology of Esophagus

An approach to the reporting of esophageal biopsies

Benign tumours and tumour -like conditions of esophagus.

1. Squamous papilloma of the esophagus

2.Inflammatory fibroid polyp of the esophagus

3. Leiomyoma of the esophagus

4. Granular cell tumour of the esophagus

5. Esophageal cysts 

6. Glycogenic acanthosis 

Reporting of esophageal resection specimens

Squamous epithelial dysplasia  including squamous cell carcinoma in-situ of the esophagus

Small cell carcinoma of the esophagus 

Drug related lesions of the gastrointestinal tract.

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