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Pathological clues to benign lesions
include good symmetry, V-shaped silhouette, absent epidermal invasion,
uniform cellularity, deep maturation, absent or rare dermal mitoses and
clustered Kamino bodies. Features more commonly present in melanomas
include asymmetry, peripheral epidermal invasion, heavy or "dusty"
pigmentation, deep and abnormal dermal mitoses, HMB45 positivity in deep
dermal melanocytes, vascular invasion, neurotropism and satellites.
BENIGN MELANOCYTIC LESIONS
CAUSING DIAGNOSTIC PROBLEMS WITH MELANOMA:
VARIANTS OF
MELANOMA THAT CAN SIMULATE BENIGN LESIONS :
Further reading:
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May 2007
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