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   Desmoplastic/Spindle cell
/Neurotropic Melanoma

  Dr. Sampurna Roy  MD

 

 
      DermPath-India

          

http://www.histopathology-india.net/dermpath.htm

 

        

Pathological clues to benign lesions include good symmetry, V-shaped silhouette, absent epidermal invasion, uniform cellularity, deep maturation, absent or rare dermal mitoses and clustered Kamino bodies. Features more commonly present in melanomas include asymmetry, peripheral epidermal invasion, heavy or "dusty" pigmentation, deep and abnormal dermal mitoses, HMB45 positivity in deep dermal melanocytes, vascular invasion, neurotropism and satellites.

BENIGN  MELANOCYTIC  LESIONS  CAUSING  DIAGNOSTIC  PROBLEMS  WITH  MELANOMA:

1. ANCIENT NAEVUS:                               

2. BALLOON NAEVUS:

3. BLUE NAEVUS AND VARIANTS:

4. COMBINED NAEVUS:

5. CONGENITAL NAEVUS:

6. DEEP PENETRATING NAEVUS: 

7. DYSPLASTIC NAEVUS:

8. SPITZ NAEVUS AND VARIANTS-

9. HALO NAEVUS:

10. NAEVUS  IN GENITAL REGIONS:

11. RECURRENT NAEVUS:

                 

VARIANTS OF MELANOMA THAT CAN  SIMULATE  BENIGN LESIONS :

1. DESMOPLASTIC  MELANOMA:

2. SPITZOID MELANOMA
:

3. BALLOON CELL MELANOMA :     

4. REGRESSED  MELANOMA:               
             
5. NAEVOID MELANOMA:            

Further reading:

Problematic pigmented lesions: approach to diagnosis. J Clin Pathol 2000; 53:409-418.

Melanocytic lesions of the face: Diagnostic Pitfalls.Ann Acad Med Singapore 2004;33(Suppl):3S-14S.  (pdf file)

Pulmonary Pathology Online

Examination of pulmonary and pleural biopsies ; Percutaneous Needle and Trucut Biopsy Specimen  ; Bronchial Biopsy Specimen  ;Transbronchial Biopsy Specimen  ; Transbronchial biopsy in lung transplant recipients  ; Open lung biopsy  ; Lobectomy and pneumectomy specimen ; Histopathological reporting of pulmonary parenchymal biopsies ;Useful chromatic and immuno-stains in pulmonary pathology ;Congenital Cystic Adenomatoid Malformation ; Chondroid Hamartoma ; Acute Respiratory Distress Syndrome ; Neonatal Respiratory Distress Syndrome ; Complications of Neonatal Respiratory Distress Syndrome Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis) ; Chronic Obstructive Pulmonary Disease ;Bronchial Asthma ; Bronchiectasis ; Chronic Bronchitis  ; Emphysema ;Bronchiolitis ; Lipid Pneumonia (Paraffinoma) ; Pulmonary Alveolar Proteinosis ;Pulmonary Thromboembolism ; Other forms of  Pulmonary Embolism ; Pulmonary Infarction ; Pulmonary Hypertension ; Pulmonary Collapse (Atelectasis) and Pneumothorax ; Pulmonary Edema ; Pulmonary Hemorrhage (Eg. Goodpasture's Syndrome) ; Sarcoidosis ; Lymphangioleiomyomatosis ; Localized Fibrous Tumour of the Pleura ; Pulmonary Lymphoproliferative Disease ; Lymphomatoid Granulomatosis ;Post-Transplant Lymphoproliferative Disease ;Biphasic Epithelial/ Mesenchymal Lung Tumours ;Pulmonary Carcinosarcoma ; Pulmonary Blastoma ;Large Cell Neuroendocrine tumour ;

                 

 
 August  2009
  Gastrointestinal Stromal Tumour

      

http://www.histopathology-india.MelanocyticTumours.htm

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Melanocytic tumours
              
1. Acquired Melanocytic Naevus

Ancient Naevus  
Halo naevus
Balloon cell naevus  
Combined Naevus
Recurrent melanocytic naevus

                   
2. Spindle and epithelioid cell naevi

Spitz naevus
Pigmented spindle cell naevus

3. Blue naevi

Common blue naevus 
Cellular blue naevus


4. Dermal melanocytoses

Naevus of Ota

Naevus of Ito  
Mongolian spot  

5. Congenital melanocytic naevi

6. Dysplastic melanocytic naevi                                       

Pigmented melanocytic lesions causing diagnostic problems

Prognostic parameters of melanoma

Lentigo maligna melanoma

Superficial spreading  melanoma

Nodular melanoma


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