HISTOPATHOLOGY INDIA.COM    Myxoid Tumours of Soft Tissue

 

               

The thyroid harbours metastases, surprisingly, in 20% of patients dying of   disseminated carcinoma. Metastases, therefore, enter the differential      diagnosis of all thyroid tumours.

In a case of metastatic colonic carcinoma to the thyroid the patient           usually has a past medical history of colonic carcinoma and the          histological and mucin histochemical features confirm the diagnosis.    

Renal cell carcinoma is a notorious and confusing source of intra-thyroid       metastases. 

A review of the literature reveals that colon, melanoma, breast, renal,            and lung carcinomas are the most frequent tumours to metastasize to               the thyroid.

Metastatic disease must be considered in the differential diagnosis of              cold nodules on radionuclide thyroid scans, particularly in patients with               a known primary.

                         

Colon carcinoma metastasis to the thyroid gland: report of a case with a review of the literature.Tumori. 2006 May-Jun;92(3):252-6.

Metastasis of colon cancer to the thyroid gland is very rare and we would like to report a case we have experienced, with a review of the literature. A 66-year-old woman noticed a swelling in the anterior neck area and sought medical attention at our department in August 2003. At age 63, she had undergone surgery for cancer of the ascending colon, but subsequently the cancer metastasized to the liver and she underwent an outer hepatic segmentectomy. Fine-needle aspiration cytology indicated adenocarcinoma with characteristic tall columnar cells, confirming our suspicion that metastasis from the ascending colon cancer had already occurred. Furthermore, lung metastasis was also suspected, because several nodules were found in the lungs. On August 13, resection of the left lobe of the thyroid gland and dissection of the cervical lymph nodes were performed. Histopathology showed metastasis of the ascending colon cancer to the thyroid and lymph nodes.

Colon cancer metastatic to the lung and the thyroid gland.Arch Surg. 2006 Jan;141(1):93-6.

The clinical diagnosis of primary thyroid cancer is uncommon, constituting 1.5% of all cancers in the United States. Clinically diagnosed metastatic cancer to the thyroid gland is rare. Colon cancer is one of the most common cancers in the United States, with a high propensity to metastasize; 30% to 40% of patients have metastatic disease at the initial diagnosis. The most common sites of metastasis from colon cancer are the regional lymph nodes, the liver, the lung, and the peritoneum. Colon cancer metastasis to the thyroid gland is rare, with only a few reported cases, mainly in the pathology literature. These cases describe metastasis from colon cancer to the thyroid gland that became apparent years after the initial diagnosis of colon cancer and were usually associated with dissemination to the liver, the lung, or both. We report a case of colonic adenocarcinoma metastatic to the thyroid gland and lung without involvement of the liver. A review of the literature is also included.

Colonic carcinoma metastasis to the thyroid: a case of skip metastasis. J Laryngol Otol. 2005 Oct;119(10):834-6.

Colonic carcinoma metastasis to the thyroid is rare. Here the authors present the case of an 81-year-old lady who presented with metastatic colonic adenocarcinoma in her thyroid gland. This case is unique as it is the first to demonstrate metastasis from the colon to the thyroid with no other site involvement. The use of cytokeratin immunohistochemical staining is reviewed along with the current perspectives on the concept of skip metastasis.

Metastatic thyroid tumors from adenocarcinoma of the colon: clinical and anatomo-pathological contribution. Tumori. 2003 Jul-Aug;89(4 Suppl):220-2.

We report herein the case of a 43 year-old man who was operated 1998 of left colectomy and hepatic resection for colic adenocarcinoma metastasized in the liver. He suffers of multinodular goiter from some years; was admitted to our hospital with a 2-month history of enlargement of goiter and appearance of a new nodule. Physical and imaging examinations disclosed a new nodules in the thyroid. Was operated of total thyroidectomia and lymphoadenectomia cervical in the December 2002. Histologic examinations revealed adenocarcinoma which was consistent with a diagnosis of metastases from the primary colon adenocarcinoma to the thyroid. The rarity, diagnosis, and prognosis of thyroid metastasis from colon carcinoma are discussed.

Thyroid metastases from colon cancer case report in a long term survivor.J Exp Clin Cancer Res. 2003 Dec;22(4 Suppl):243-5.

Colon cancer usually has an hematogenous spread to liver and lung: rarely, or in the case of most advanced disease, also brain and bone can be involved. Thyroid metastasis is generally thought to be infrequent, breast and kidney cancer being the most frequent causes. Herein we present the case of a man affected by liver metastasis from colon cancer, who developed unusual metastasis to thyroid.

Diagnosis of thyroid metastasis of colonic adenocarcinoma by fine needle aspiration biopsy. Acta Cytol. 1990 May-Jun;34(3):363-5.

A case of thyroid metastasis from colonic adenocarcinoma was diagnosed by fine needle aspiration (FNA) biopsy. The FNA specimen from the thyroid nodule contained tall columnar cells consistent with the intestinal primary. Staining of the tumor cells for thyroglobulin was negative. Histologic examination of the excised nodule, which was removed due to its rapid growth and risk of skin ulceration, confirmed the FNA diagnosis. FNA biopsy in such cases should be able to distinguish between a second primary neoplasm, which would be removed, and a metastasis, which would usually not be surgically treated.

Colon carcinoma metastatic to the thyroid gland.Clin Nucl Med. 1986 Sep;11(9):634-5.

Metastatic carcinoma to the thyroid gland rarely is encountered in clinical practice; however, autopsy series have shown that it is not a rare occurrence. A case of adenocarcinoma of the colon with metastases to the thyroid is reported. A review of the literature reveals that melanoma, breast, renal, and lung carcinomas are the most frequent tumors to metastasize to the thyroid. Metastatic disease must be considered in the differential diagnosis of cold nodules on radionuclide thyroid scans, particularly in patients with a known primary.
 


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