Custom Search



Soft Tissue Pathology

Pathology of Morton's Neuroma (Morton's Metatarsalgia)


Dermatopathology Quiz Case 209

Diagnosis: Morton's Neuroma (Morton's Metatarsalgia)




Morton's neuroma is mechanically induced degenerative neuropathy which has a strong predilection for the third common digital nerve in middle-aged women. 

This non-neoplastic lesion was described by Thomas Morton in 1876.

Cause: It commonly occurs in female adults and is probably related to nerve compression against the intermetatarsal ligament from foot position in high-heeled shoes or due to ischaemia.  

Clinical presentation: Patient complains of severe pain in the sole of the foot, in the region of the metatarsal heads or metatarsophalangeal joints.

Site: There is perineural fibrosis of the plantar digital nerve.  The nerve is usually affected at the level of the metatarsal head and is common between the third and fourth metatarsals and  then between the second and third.

Gross: There is thickening or fusiform swelling of the plantar digital nerve at its bifurcation, with thickening of adjacent tendosynovial tissues.

Microscopic features: There is prominent endoneurial, perineurial and epineurial fibrosis and hyalinization associated with loss of axons. 

There is fibrosis and thickening of the blood vessel wall.

Further reading:

Morton's neuroma.

Histological comparison of the third interdigital nerve in patients with Morton's metatarsalgia and control patients.

Morton's intermetatarsal neuroma: morphology and histological substrate.

Morton's metatarsalgia: sonographic findings and correlated histopathology.

Morton's interdigital neuroma: a clinical review of its etiology, treatment, and results.

Thomas George Morton metatarsalgia






Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen




Privacy Policy  

Advertising Policy

Copyright 2018