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Endocrine Pathology Online

Multinodular Goitre containing foci of Squamous Metaplasia

Dr Sampurna Roy MD




Squamous cells in and around the thyroid can cause diagnostic problems, especially on head-and-neck region frozen sections.

It is necessary to demonstrate unequivocal pleomorphism before a diagnosis of squamous carcinoma can be made.

Squamous cells are seen as a metaplastic phenomenon in multinodular goiter, autoimmune thyroiditis, congenitally as solid cell nests  (ultimobranchial body remnants), and normally in the Hassall's corpuscles  of the thymus. 


Further reading

Squamous metaplasia in a multinodular goiter: a case report.

Extensive squamous metaplasia in nodular goiter--a diagnostic dilemma in the fine needle aspiration (FNA) cytology--a case report.

Squamous cells in the human thyroid gland.

Cystic goiter with squamous-cell metaplasia--case report and comment on origin of squamous-cell cyst.

Massive squamous metaplasia of the thyroid gland-- report of three cases.

Squamous epithelium in the human thyroid gland.

Unusual non-neoplastic lesions in the "surgical pathology" of the thyroid .



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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