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Pathology of Omsk Hemorrhagic Fever

Dr Sampurna Roy MD





Omsk hemorrhagic fever virus, is the only known tick-borne flavivirus to cause hemorrhagic disease in humans in the absence of encephalitis.

Omsk hemorrhagic fever resembles Crimean fever and was first described in the Asiatic USSR (1947).

Endemic to the forested steppe-lake region of western Siberia, its animal reservoir is principally rodents.

Infections in humans come from the bites of infected ticks or from contact with muskrats killed by hunters, in which case the muskrats were bitten by ticks infested with the virus from small rodents.

Omsk hemorrhagic fever virus can be transmitted through the milk of infected goats or sheep and isolated from aquatic animals and water.

Symptoms of Omsk hemorrhagic fever virus includes fever, headache, severe muscle pain, cough, dehydration, gastrointestinal symptoms and bleeding problems.

After 1-2 weeks of symptoms, some patients recover without complication.

In most patients in the beginning of the third week the symptoms include fever and signs of encephalitis.

The diagnosis is made by virus isolation from blood or by serologic testing using enzyme-linked immunosorbent serologic assay (ELISA).



Further reading:

Omsk haemorrhagic fever.

The deduced evolution history of Omsk hemorrhagic fever

Omsk haemorrhagic fever : The Lancet

[Mixed infection with tularemia and Omsk hemorrhagic fever

[Morphological study of Omsk hemorrhagic fever (OHF) virus

[Remote sequelae of Omsk hemorrhagic fever].

Hemorrhagic fever viruses as biological weapons: medical and public health management

An animal model for the tickborne flavivirus—Omsk hemorrhagic fever virus

[Omsk hemorrhagic fever--current status of the problem]

Comparative analysis of immune responses to Russian spring–summer encephalitis and Omsk hemorrhagic fever viruses in mouse models

Structure of the envelope protein domain III of Omsk hemorrhagic fever virus.

Molecular determinants of antigenicity of two subtypes of the tick-borne flavivirus Omsk haemorrhagic fever virus.

Analysis of the complete genome of the tick-borne flavivirus Omsk hemorrhagic fever virus.

Omsk hemorrhagic fever--current status of the problem.

The clinico-epidemiological characteristics of Omsk hemorrhagic fever in 1988-1992.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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