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12 Amazing Facts you probably didn't know about Oncocytic Lipoadenoma of the Salivary Gland

 

Dr Sampurna Roy MD   

 

 

 

 

 

  
 

Oncocytic lipoadenoma.

(A) Computed tomography reveals a heterogeneous tumor with a fat component (arrow).

(B) Grossly, the cut surface is a mixture of tan and yellow components.

(C) The scanning view shows an encapsulated tumor with biphasic components and surrounded by normal acini.

 

 

 (A) Oncocytic cells are arranged in an acinar or glandular pattern.

 (B) The arrows indicate foci of sebaceous differentiation.

DOG1 expression is seen in normal parotid acinar cells (C) but not oncocytic cells (D).

 

 

 

 

 

 

Chi C, Kuo T, Lee L. Oncocytic Lipoadenoma: A Rare Case of Parotid Gland Tumor and Review of the Literature. Journal of Pathology and Translational Medicine. 2015;49(2):144-147.

 

 

(1) Oncocytic Lipoadenoma was first described in 1998,  by Dr M. Hirokawa et al ( Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan)

 

 

(2) Dr M. Hirokawa et al reported this tumour in a 66-year-old Japanese woman who presented with a left submandibular mass.

 

 

(3) This tumour is still not included in the current WHO classification of salivary gland neoplasms.

 

 

(4) Oncocytic lipoadenoma is an exceedingly rare neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Only 20 cases have been reported in the literature.

 

 

(5) Lipoadenoma and adenolipoma are tumours composed of epithelial and lipomatous elements and have been described in many anatomic sites, including the skin, breast, parathyroid, thyroid, and salivary gland.

Oncocytic lipoadenoma, where the epithelial component consists of oncocytes has been reported only in salivary glands ( parotid and submandibular glands).

 

 

(6) This tumour has not been reported in any minor salivary glands.

 

 

(7) The appearance of the cut surface of the tumour may vary from tan to brown to yellow, depending on the amount of adipose tissue present.

 

 

(8)  The tumours are composed of a mixed population of oncocytes and adipocytes in varying proportions . The oncocytes are round to polygonal with distinct cell borders and abundant granular, eosinophilic cytoplasm, arranged in nests and small acini.

The adipocytic component of the tumours range from 5 to 70 % and the adipocytes have the appearance of mature fat.

The oncocytes either show close intermingling with the fatty cells or they may form discrete circumscribed oncocytic nodules within a lipoma-like background.

Neither the oncocytic nor the lipomatous components of the tumors show any cellular pleomorphism or mitoses.

 

 

(9)  The majority of the reported oncocytic lipoadenomas  exhibit sebaceous differentiation.

 

 

(10)   Among the various salivary gland tumors with a prominent oncocytic component, oncocytic lipoadenoma is most likely to be mistaken for oncocytoma. Both are well circumscribed tumours comprised of classical eosinophilic oncocytic cells. Oncocytomas, however, are composed exclusively of oncocytes and lack the lipomatous component characteristic of oncocytic lipoadenoma.

 

 

(11)   The presence of adipose tissue similarly allows for separation of oncocytic lipoadenoma from stroma poor Warthin tumour, Warthin tumour with nodular oncocytic proliferation, and oncocytic pleomorphic adenoma.

 

 

(12)   The differential diagnosis also includes sialolipoma. Sialolipoma is characteristically composed predominantly of adipose tissue with admixed islands of salivary gland acini, ductal, myoepithelial and basal cells.

 

 

 

 

Source

 

Chi C, Kuo T, Lee L. Oncocytic Lipoadenoma: A Rare Case of Parotid Gland Tumor and Review of the Literature. Journal of Pathology and Translational Medicine. 2015;49(2):144-147.

 

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

 

Fat-Containing Salivary Gland Tumors: A Review

 

Oncocytic Lipoadenoma of Submandibular Gland: A Case Report

 

Oncocytic lipoadenoma of the parotid gland: a report of a new case and review of the literature

 

 

 

 

 

 

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