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Pathology of Cutaneous Ossification (Osteoma Cutis)

Dr Sampurna Roy MD             





Osteoma cutis, also called cutaneous ossification is a rare disorder characterized by compact bone formation in the dermis and subcutaneous tissue.

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Cutaneous ossification may be primary or secondary due to either inflammatory or neoplastic processes.

It is classified as primary when it occurs in the absence of a demonstrable preexisting lesion.

Secondary cutaneous osteomas are correlated with inflammatory processes, scars, or dysembryoplasia.

These lesions have been most commonly reported occurring with pilomatrixoma,basal cell carcinoma, acne vulgaris, and melanocytic nevi.

Platelike osteoma cutis is a rare congenital disorder and is associated with abnormal ossification of cutaneous or subcutaneous tissue.

Cutaneous ossification may be a feature of Albright's hereditary osteodystrophy.

Miliary osteoma of the face is a form of primary osteoma cutis that generally occurs in middle-aged and older adult women.

These lesions present as multiple hard flesh coloured papules on the face.

Histologically, the osteomas are composed of well-formed small bony spicules or large masses of bone with prominent cement lines and calcification.

They may demonstrate osteoblasts, osteoclasts, and osteocytes and occasionally may even demonstrate bone marrow elements.


[Microscopic images of Osteoma Cutis (Primary Cutaneous Ossification)]

Further reading:

Evaluation and management of multiple miliary osteoma cutis: case series of 11 patients and literature review.

Infantile osteoma cutis as a presentation of a GNAS mutation.

Miliary osteoma cutis of the face.

Osteoma cutis (nevus of nanta) of the eyebrow.

Multiple cutaneous osteomas of the face in a setting of chronic acne.

Epidermolytic hyperkeratosis and congenital platelike osteoma cutis in a child.

Osteoma cutis presenting as an erythematous and grainy, retroauricular plaque.

Osteoma cutis as a sequela to facial acne: a case report.

Osteomas of the skin revisited: a clinicopathologic review of 74 cases.

Progressive extensive osteoma cutis associated with dysmorphic features: a new syndrome? Case report and review of the literature.

Congenital plate-like osteoma cutis of the forehead: an atypical presentation form.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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