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Ear Pathology Online

Pathology of Otosclerosis

Dr Sampurna Roy MD    




Otosclerosis is a bone disease of the human otic capsule, which is among the most common causes of acquired hearing loss.

The pathologic process is characterized by a wave of abnormal bone remodeling in specific sites of predilection within the endochondral layer of the temporal bone. 

Although the cause of otosclerosis remains uncertain, there is a clear genetic predisposition with half of all cases occurring in families with more than one affected member.

There is also compelling evidence that measles virus may play a role in some cases.

Otosclerosis may fix the stapes by a tiny bridge of abnormal bone or may totally obliterate it.

It may spread to the cochlea to produce either a sensorineural loss of varying degree or deafness.

Lesions may be sclerotic, spongiotic, or fibrous but usually comprise all these histologic types.

This diversity of size and anatomic distribution coincides with the variable types of hearing loss, from a mild conductive deficit to a total loss.


Further reading

Is it possible to predict diffuse obliterative otosclerosis preoperatively by audiologic examination.

Otosclerosis of the incus.

Phenotype-genotype correlations in otosclerosis: clinical features of OTSC2.

Measles virus prevalence in otosclerotic foci.

Measles virus and otosclerosis.

Dynamic bone studies of the labyrinthine capsule in relation to otosclerosis.

Expression of collagens in the otosclerotic bone

Histologic otosclerosis is associated with the presence of measles virus in the stapes footplate.

Two subgroups of stapes fixation: otosclerosis and pseudo-otosclerosis.

Histopathology of otosclerosis.

Inner ear inflammation and round window otosclerosis.

Cochlear vascular pathology and hydrops in otosclerosis.

Otosclerosis and associated otopathologic conditions

Molecular biology of otosclerosis

Otosclerosis associated with Ménière's disease: a histological study.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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