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Paediatric Pathology Online

Pathology of Pediatric Salivary Gland Lesions

Dr Sampurna Roy MD 





Salivary gland epithelial tumours are rarer, present mainly as parotid masses in female adolescents and are also more likely to be malignant than in the adult.  

Pleomorphic adenoma is the commonest benign tumour and low grade mucoepidermoid carcinoma and acinic cell tumours are the commonest malignant tumours.

Other causes of a salivary gland mass include chronic sailadenitis, cat scratch disease , atypical mycobacterial infection , mucocoele and reactive intraglandular lymph node.

In infancy hemangiomas, cavernous or juvenile predominate. Juvenile hemangioma is often highly cellular, replaces normal parenchyma, surrounds ducts and acini, and has plump nuclei and frequent mitoses.

However the lobular appearance of the gland is preserved, pleomorphism is absent and a careful search for small small vascular lumens and immunohistochemistry for vascular markers all aid correct diagnosis. Cellular Hemangioma of Infancy.

Sialoblastoma is a very rare congenital tumour of infancy, usually involves the parotid and typically has an organoid pattern with solid nests of epithelial cells and small ducts.

The majority are benign. However 25% of cases show features of malignancy with necrosis, anaplasia, vascular and perineural invasion.


Further reading:

Pediatric salivary gland lesions.

Sialoblastoma: a case report and review of the literature on congenital epithelial tumors of salivary gland origin.

Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 second malignant neoplasms.

Clinical characteristics and survival for major salivary gland malignancies in children.

Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.

Sialoblastoma and epithelial tumors in children: their morphologic spectrum and distribution by age.

Salivary gland neoplasms in children.

Salivary gland neoplasms in children: a 10-year survey at the Children's Hospital of Philadelphia.

Salivary gland disease in infancy and childhood: non-malignant lesions.

Salivary gland disease in children: a review. Part 1: Acquired non-neoplastic disease.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


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