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Pathology of Papillary Eccrine Adenoma

Dr Sampurna Roy MD         


Dermatopathology Quiz Case 131

Diagnosis : Papillary Eccrine Adenoma




Papillary eccrine adenoma, a rare benign adnexal tumour, was first described in 1977. Papillary eccrine adenoma. Arch Dermatol. 1977;113(5):596-8.

Clinical presentation:  Firm or hard nodules, frequently of many years' duration, and a large proportion are situated on the extremities.

Microscopic features:

Symmetrical lesion ;

Tumour is composed of dilated duct-like structures of various sizes with intraluminal papillary projections ;

Ducts are lined by two or more layers of cells ;

Inner layer often forms one or multiple papillae of variable complexity ;

Lumina contains eosinophilic amorphous material ;

Fibrous stroma around the lesion is well separated from the surrounding dermis  ;

Stroma consists of patches of loosely arranged spindled cells and areas of hyalinized collagen.

Other features -  focal squamous differentiation ; clear cell change ; connection of ducts to the epidermis ; prominent nerves within the stroma.

'Tubulopapillary hidradenoma' is a term proposed to describe lesions with both eccrine and apocrine differentiation.

It encompasses a spectrum of lesions that includes tubular apocrine adenoma and papillary eccrine adenoma.


Demonstrated immunoreactivity to S-100 protein, carcinoembryonic antigen, and epithelial membrane antigen.


Differential diagnosis: The differential diagnosis includes other cutaneous neoplasms with intraductal papillary proliferation.


Further reading:

Papillary eccrine adenoma in association with cutaneous horn.

Papillary eccrine adenoma should not be mistaken for aggressive digital papillary adenocarcinoma.

Papillary eccrine adenoma.

Papillary eccrine adenoma of the heel: a case report.

Papillary eccrine adenoma: immunohistochemical study and literature review.

Papillary eccrine adenoma: an ultrastructural and immunohistochemical study.

Papillary eccrine adenoma: immunohistochemical studies of keratin expression.

Papillary tubular adenoma with marked tubular vacuolization. 




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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