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Pulmonary Pathology Online

Pathology of Pulmonary Adenofibroma

Dr Sampurna Roy MD   




Pulmonary adenofibroma are rare lung lesion.

Age:  Usually noted in adults.

Gross: Small and well circumscribed lesion.

Microscopic features: Complex branching glandular spaces lined by a single layer of cuboidal to columnar epithelium. The tumour is surrounded by a spindle cell fibrous stroma.

Immunohistochemistry: Epithelial lining cells show positive staining for cytokeratin and epithelial membrane antigen (EMA). The stroma is negative for S100-protein, actin, keratin, EMA, desmin and CD34.

Differential diagnosis:  Their main importance lies in distinguishing them histologically from other types of pulmonary hamartomas, pulmonary blastomas , intrapulmonary solitary fibrous tumour , and metastases from soft tissue and visceral sarcomas.

Further reading:

Pulmonary adenofibroma: cytologic and clinicopathologic features of a rare benign primary lung lesion.

Pulmonary adenofibroma in a middle-aged man: report of a case.

Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited.

Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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