Custom Search



Pulmonary Pathology Online

Pathology of Nodular Pulmonary Amyloid (Pulmonary Amyloidoma)

Dr Sampurna Roy MD         


Amyloidosis includes a spectrum of diseases associated with an abnormal extracellular deposition of amyloid.  

Amyloid deposition can occur in association with inflammatory, hereditary, or neoplastic entities.

The respiratory system is involved in approximately 50% of patients with amyloidosis.

In the lung amyloid deposition may be localized or diffuse and may have a variety of appearances.

On average, affected patients are in the 6th decade of life.

Nodular amyloidosis is usually asymptomatic and thus found incidentally.

Atelectasis and secondary bronchiectasis due to obstruction of a bronchus have been reported.

Three forms of Primary pulmonary amyloidosis: 

 i) Tracheobronchial ii) Nodular parenchymal, and iii) Alveolar septal.

Tracheobronchial amyloidosis is the most frequent manifestation of pulmonary amyloidosis.

Nodular pulmonary amyloidosis is a limited form of amyloidosis.

It is characterized by  single or multiple intrapulmonary nodules or masses and is also known as amyloidoma.

Amyloidoma usually occur in the lower lobes.

These may be mistaken as a tumour.

The lesion may calcify or undergo osseous metaplasia.

Resection of these nodules is both diagnostic and curative.

Usually nodular pulmonary "amyloidomas"  are characterized by a benign course.

According to recent studies the association of nodular pulmonary amyloidoma with autoimmune disease and lymphoma indicate the majority of these lesions relate to an underlying lymphoplasmacytic neoplasm in the spectrum of MALT lymphoma.

Despite its localized nature, tracheobronchial amyloid deposition may be asymptomatic or may result in significant morbidity due to obstructive phenomena.

Pulmonary amyloidosis associated with primary systemic amyloidosis generally presents as a diffuse interstitial pattern with or without pleural effusion.

Imaging Features: 

Imaging of nodular amyloidosis shows solitary or multiple nodules with a smooth or lobular contour.

Nodules are often seen in a subpleural or peripheral location .

Calcification may occur in up to 50% of nodules seen at CT scan.

Pathologic features: 

Gross examination:  Amyloid nodules are either yellow, gray, or pale tan.

The nodules range in size from 0.6 to 15 cm.

Larger lesions may cavitate or exhibit hemorrhage, necrosis, fibrosis, or calcification.

Microscopic features: 

Amyloid appears as an amorphous sheet of eosinophilic extracellular material that surrounds vessels.

The protein takes up Congo red stain and exhibits apple-green birefringence at polarized microscopic analysis.    

Differential diagnosis:   Primary or metastatic neoplasms.  

Amyloid-like nodules should be distinguished from nodular amyloidosis and, in some patients, might represent a localized form of light-chain deposition.


Further reading

The pattern of amyloid deposition in the lung.

Hemoptysis in primary pulmonary amyloidoma treated with intrabronchial arterial coiling.

Primary amyloidoma of lung treated with radiation: A rare case report.

Nodular pulmonary amyloidosis is characterized by localized immunoglobulin deposition and is frequently associated with an indolent B-cell lymphoproliferative disorder.

Nodular pulmonary amyloidosis. Diagnosis by transbronchial biopsy.

Nodular pulmonary amyloidosis.

Primary pulmonary nodular amyloidosis.

Amyloid-like pulmonary nodules, including localized light-chain deposition: clinicopathologic analysis of three cases.

Localized amyloidosis of the respiratory system: CT features.

Nodular amyloidosis of the lung from intravenous drug abuse: an uncommon cause of multiple pulmonary nodules.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen





Privacy Policy  

Advertising Policy

Copyright 2019