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Anatomical Distribution of Pulmonary Disease

                                                 

Dr Sampurna Roy MD       


 

 

 

                                                                                                                      

 

Conducting Airways: Bronchial / Bronchiolar Disorders:

1.Granulomatous : 

Mycobacterial (Tuberculosis), fungal (Fungal Infections), bronchocentric granulomatosis (allergic, fungal, mucoid impaction, connective tissue disease)

2.Non-granulomatous:

Bronchopneumonia , lymphocytic and obliterative bronchiolitis (Transplant rejection, viral, toxin, foreign body, connective tissue disease).

3.Extracellular deposits:

Bone/cartilage (tracheobronchopathia osteoplastica), amyloid (tracheobronchial).

 


Angiocentric Disorders:

1. Vasculitides:   

Wegener’s granulomatosis ; Churg - Strauss syndrome ; Necrotizing sarcoid granulomatosis ; Lymphomatoid Granulomatosis .

2. Hypertensive:   

Pulmonary Hypertension   Plexigenic arteriopathy ; Thrombotic arteriopathy ; Hypoxic arteriopathy ; Congestive vasculopathy ; Vaso-occlusive disease.

 

Lymphangio centric Disorders:   

Pneumoconioses; Lymphangitis carcinomatosa / malignant lymphoma ; Lymphangio-leiomyomatosis ; Sarcoidosis.

 


Alveolar Disorders :

1. Acellular : 

Edema , Pulmonary Alveolar Proteinosis  , pneumocystis.

2. Cellular :  

Erythrocytes:

Hemorrhagic - Goodpasture’s syndrome, systemic lupus erythematosus , drugs , chronic mitral stenosis, pulmonary venous occlusion, pulmonary hypertension , pulmonary hemosiderosis.

Neutrophils:

Bacterial pneumonia. 

(Lobar Pneumonia ;Broncho-pneumonia )

                                                          Eosinophils: 

Eosinophilic pneumonia, allergy, parasites.

Macrophages:  

Desquamative  interstitial pneumonia , smoking, Tuberculosis ,Legionella , Lipid Pneumonia.   

 


Interstitial Disorders :      

1. Non-granulomatous:  

Acute interstitial pneumonia, non-specific interstitial pneumonia , usual interstitial pneumonia (+/-), asbestosis , viral pneumonitis, Langerhans cell histiocytosis.

2. Granulomatous: 

Tuberculosis , fungi, sarcoid, extrinsic allergic alveolitis, pneumoconiosis (talc ,hard metal-beryllium , aluminium ).

3. Extracellular Deposits: 

Calcium (calcinosis, dystrophic, psammoma bodies, blue bodies); Amyloid (nodular - amyloidoma, diffuse - alveolar septal)

 


                               

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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