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Pulmonary Pathology Online

Pathology of Ganglioneuroblastoma of the Lung

Dr Sampurna Roy MD        


Ganglioneuroblastomas are extremely rare tumour of the lung.

Clinically, the tumour usually occurs in adults and presents with obstructive symptoms.

The tumour grossly presents as a well circumscribed, endobronchial lesion (up to 5cm in diameter).

The tumour consists of composed of small cells with indistinct cell borders, round to oval nuclei and inconspicuous nucleoli and moderately amounts of eosinophilic cytoplasm.

Nissl granules are present in the cytoplasm indicating their ganglionic differentiation. The cells are embedded in a neuropil-rich matrix.

Immunohistochemistry: Variable positivity for neurofilament protein, S-100 protein and GFAP.

The tumour may invade adjacent organs and metastasize to hilar lymph nodes.


Further reading:

Primary pulmonary ganglioneuroblastoma: a clinicopathologic and immunohistochemical study of two cases.

Combined carcinoid tumor and ganglioneuroblastoma of the lung: a case report.

Primary pulmonary ganglioneuroblastoma in an adult: maturation, involution and the immune response.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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