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Pulmonary Pathology Online

Lymphoproliferative Diseases of the Lung

 Dr Sampurna Roy MD




The lymphoproliferative disorders represent a spectrum of lymphoid abnormalities that can involve the chest.


Plasma cell granuloma, mucosa-associated lymphoid tissue lymphoma , posttransplantation lymphoproliferative disorders, lymphoid interstitial pneumonia, follicular bronchiolitis and lymphomatoid granulomatosis involve the pulmonary parenchyma, whereas Castleman's disease, infectious mononucleosis, and angioimmunoblastic lymphadenopathy with dysproteinemia involve intrathoracic lymph nodes.


Recent immunohistochemical techniques give us a better understanding of the lymphoproliferative disorders.


Clinical and radiologic features often allow differentiation of the lymphoproliferative disorders from the more common aggressive lymphomas.




1. B-cell non-Hodgkin’s MALT lymphomas

- Low grade ; High grade ; High with low grade areas.

2. Reactive pulmonary lymphoid hyperplasia: Lymphocytic Interstitial Pneumonia / Follicular Bronchiolitis

3. Lymphomatoid granulomatosis

4. Post transplant lymphoproliferative disorders

5. Secondary involvement by other types of lymphomas and reactive lymphoid conditions.


Further reading:

Lymphoproliferative lung disorders: clinicopathological aspects.

Lymphoproliferative neoplasms of the lung: a review.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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