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Pulmonary Pathology Online

Pathology of Salivary Gland-Type Mixed Tumour of the Lung

Dr Sampurna Roy MD    


Salivary gland-type mixed tumor primarily arising in the lung is extremely rare.

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Microscopically, the tumour exhibits almost the same features as those of mixed tumour of the salivary gland intermingled with chondromyxoid stroma, glandular component, solid growth pattern of myoepithelial components and well-developed cartilage formation, exhibiting a sharp margin.

Immunohistochemical studies show strong positivity of the cells in the epithelial component with low molecular weight keratins (CAM 5.2), and to a lesser extent with broad spectrum keratin, actin, and vimentin antibodies.

The cells also show variable reactivity in the epithelial and nonepithelial elements with S-100 protein and glial fibrillary acidic protein.

Salivary gland-type mixed tumors of the lung may present with a spectrum of histologic features and clinical behavior, ranging from benign to frankly malignant, similar to that observed for their salivary gland counterparts.

Size of the lesion at the time of presentation, extent of local infiltration, and degree of mitotic activity appear to be the most reliable prognostic features of these tumours.


Further reading:

Pulmonary salivary gland-type tumors with features of malignant mixed tumor (carcinoma ex pleomorphic adenoma): a clinicopathologic study of five cases.

Benign and malignant salivary gland-type mixed tumors of the lung. Clinicopathologic and immunohistochemical study of eight cases.

A case of salivary gland-type mixed tumor of the lung differentiating toward type II alveolar epithelial cells in glandular components with a literature review.

Malignant mixed tumor of bronchus: a biphasic neoplasm of epithelial and myoepithelial cells.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)








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