Custom Search

       

 

Pulmonary Pathology Online

Pathology of Spindle Cell Squamous Carcinoma

Dr Sampurna Roy MD

 

Syn: Sarcomatoid Carcinoma

Spindle cell squamous carcinoma is a rare histologic variant of squamous cell carcinoma. 

On light microscopic examination, the spindle cell components of the tumours are histologically characterized by sheets of fusiform spindle cells that closely resembled a sarcoma.

Immunohistochemical examination show positive staining of spindle cells for keratin, vimentin, and EMA,but not for desmin.

These results indicate that the spindle cells have characteristics of squamous epithelial cells, and differed from carcinosarcoma.

Electron microscopy show well-formed intercellular junctions and thick bundles of tonofilaments within the cytoplasm of the cells further confirming the squamous epithelial nature of the neoplasm.

It has been suggested that the spindle cell component displays a spectrum of phenotypes originating from epithelial cells with varying degrees of mesenchymal transformation.

It is difficult to establish a diagnosis of this rare primary pulmonary malignancy prior to surgical intervention.

 

Further reading:

Spindle cell carcinoma of the lung: a clinicopathologic presentation of three cases.

Biphasic and monophasic sarcomatoid carcinomas of the lung. A reappraisal of 'carcinosarcomas' and 'spindle-cell carcinomas'.

Lung carcinoma with spindle cell components: sixteen cases examined by immunohistochemistry.

A case of spindle cell (squamous) carcinoma (WHO) of the lung .

Spindle cell carcinoma of the lung. A clinicopathologic study of three cases.

Spindle cell squamous carcinoma of the lung. Immunocytochemical and ultrastructural study of a case.

Spindle cell squamous carcinoma of the lung--two case reports .

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 

 

 


 

 

Histopathology-India.net

 

Pathopedia-India.com

 

Surgical Pathology.com

 

Pathology-India.com

 

Dermpath-India

 

Infectious Disease Online

 

Pathology Quiz Online 

 

Paediatric Pathology Online

 

Pancreatic Pathology Online

 

Paraganglioma-Online

 

Endocrine Pathology Online

 

Eye Pathology Online

 

Ear Pathology Online

 

Cardiac Path Online

 

Pulmonary Pathology Online

 

Lung Tumour Online

 

Mesothelioma-Online

 

Nutritional Pathology Online

 

Environmental Pathology Online

 

Soft Tissue Tumour Online

 

GI Path Online-India

 

Gallbladder Pathology Online

 

E-book - History of Medicine  

 

Microscope - Seeing the Unseen

 

 roypath.in

 

 

Disclaimer

Privacy Policy  

Advertising Policy

Copyright 2017  histopathology-india.net