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Pulmonary Pathology Online

Pathology of Spindle Cell Squamous Carcinoma

Dr Sampurna Roy MD




Syn: Sarcomatoid Carcinoma

Spindle cell squamous carcinoma is a rare histologic variant of squamous cell carcinoma. 

On light microscopic examination, the spindle cell components of the tumours are histologically characterized by sheets of fusiform spindle cells that closely resembled a sarcoma.

Immunohistochemical examination show positive staining of spindle cells for keratin, vimentin, and EMA,but not for desmin.

These results indicate that the spindle cells have characteristics of squamous epithelial cells, and differed from carcinosarcoma.

Electron microscopy show well-formed intercellular junctions and thick bundles of tonofilaments within the cytoplasm of the cells further confirming the squamous epithelial nature of the neoplasm.

It has been suggested that the spindle cell component displays a spectrum of phenotypes originating from epithelial cells with varying degrees of mesenchymal transformation.

It is difficult to establish a diagnosis of this rare primary pulmonary malignancy prior to surgical intervention.


Further reading:

Spindle cell carcinoma of the lung: a clinicopathologic presentation of three cases.

Biphasic and monophasic sarcomatoid carcinomas of the lung. A reappraisal of 'carcinosarcomas' and 'spindle-cell carcinomas'.

Lung carcinoma with spindle cell components: sixteen cases examined by immunohistochemistry.

A case of spindle cell (squamous) carcinoma (WHO) of the lung .

Spindle cell carcinoma of the lung. A clinicopathologic study of three cases.

Spindle cell squamous carcinoma of the lung. Immunocytochemical and ultrastructural study of a case.

Spindle cell squamous carcinoma of the lung--two case reports .



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)








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