Spindle cell squamous carcinoma is a rare histologic variant of squamous cell carcinoma.
On light microscopic examination, the spindle cell components of the tumours are histologically characterized by sheets of fusiform spindle cells that closely resembled a sarcoma.
Immunohistochemical examination show positive staining of spindle cells for keratin, vimentin, and EMA,but not for desmin.
These results indicate that the spindle cells have characteristics of squamous epithelial cells, and differed from carcinosarcoma.
Electron microscopy show well-formed intercellular junctions and thick bundles of tonofilaments within the cytoplasm of the cells further confirming the squamous epithelial nature of the neoplasm.
It has been suggested that the spindle cell component displays a spectrum of phenotypes originating from epithelial cells with varying degrees of mesenchymal transformation.
It is difficult to establish a diagnosis of this rare primary pulmonary malignancy prior to surgical intervention.
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