| Paediatric Pathology Online
Pathology of Salivary Gland Anlage Tumour of the Nasopharynx
Salivary gland anlage tumour of the nasopharynx (congenital pleomorphic adenoma of the nasopharynx), a rare unique pedunculated mass, smooth surfaced and up to 3 cm in size.
It is a benign hamartoma rather than a true neoplasm.
The characteristic microscopy is surface non-keratinizing squamous epithelium continuous with underlying solid and cystic squamous nests with duct-like structures plus nodules of spindle cells.
Immunoperoxidase staining showed the presence of epithelial markers in both spindle cells and epithelial structures.
Spindle cells are also reactive to vimentin and smooth muscle actin, revealing their myoepithelial phenotype.
Based on these observations, a diagnosis of salivary gland anlage tumor, also called congenital pleomorphic adenoma of the nasopharynx, is established.
The differential diagnosis includes synovial sarcoma , pleomorphic adenoma and mucoepidermoid carcinoma.
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