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Pathology of Salivary Gland Anlage Tumour of the Nasopharynx

Dr Sampurna Roy MD                     




Salivary gland anlage tumour of the nasopharynx (congenital pleomorphic adenoma of the nasopharynx), a rare unique pedunculated mass, smooth surfaced and up to 3 cm in size.

It is a benign hamartoma rather than a true neoplasm.

The characteristic microscopy is surface non-keratinizing squamous epithelium continuous with underlying solid and cystic squamous nests with duct-like structures plus nodules of spindle cells.

Immunoperoxidase staining showed the presence of epithelial markers in both spindle cells and epithelial structures.

Spindle cells are also reactive to vimentin and smooth muscle actin, revealing their myoepithelial phenotype.

Based on these observations, a diagnosis of salivary gland anlage tumor, also called congenital pleomorphic adenoma of the nasopharynx, is established.

The differential diagnosis includes synovial sarcoma , pleomorphic adenoma and mucoepidermoid carcinoma.


Further reading:

Congenital salivary gland anlage tumor of the nasopharynx.

Congenital salivary gland anlage tumor: a case series and review of the literature.

Salivary gland anlage tumor in a neonate presenting with respiratory distress: radiographic and pathologic correlation.

Congenital salivary gland anlage tumor: a case series and review of the literature.

Congenital salivary gland anlage tumor of the nasopharynx.

Salivary gland anlage tumor of the nasopharynx: a clinicopathologic and immunohistochemical study of three cases.

Salivary gland anlage tumor ("congenital pleomorphic adenoma"). A clinicopathologic, immuno histochemical and ultrastructural study of nine cases.

Salivary gland anlage tumor. A case with widespread necrosis and large cyst formation.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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