Path Quiz Case -35 Diagnosis:
Spindle Cell Hemangioma (Haemangioendothelioma)
| December 2013
Path Quiz Case 35 (Case
History and Histopathology Images)
Spindle cell hemangioma (hemangioendothelioma) is a distinct vascular lesion which was initially considered to be a low grade angiosarcoma when first described in 1986.
In recent years it has been suggested that spindle cell hemangioma is probably a vascular malformation or the lesion results from abnormalities of local blood flow.
Spindle cell hemangioma may be associated with anomalies such as Mafucci's syndrome, Klippel-Trenaunay syndrome, lymphedema and early onset varicose vein.
Treatment consists of
wide local excision without adjuvant chemotherapy or radiotherapy.
These lesions usually present as a single or multiple, often
painful, small circumscribed
reddish blue nodules.
Microscopic Images of Spindle Cell Hemangioma
- Vascular component displaying gaping thin- walled vessels containing
organizing thrombi (features resemble Cavernous hemangioma).
The spindle cells are immunonegative for endothelial marker CD34 . Most of these spindle cells stain positively for Vimentin and some cells are positive for actin and desmin.