Endocrine Pathology Online
Struma Ovarii with Papillary Carcinoma in Mature Cystic Ovarian Teratoma
Struma ovarii is an
extremely rare tumour that occasionally undergoes malignant transformation.
Struma ovarii, a teratoma in which thyroid tissue is the predominant or sole component account for 2.7% of all ovarian tumours.
Because struma ovarii is composed of thyroid tissue, it is conceivable that the pathogenetic events involved in thyroid follicular transformation may take place also in struma ovarii.
Pathogenesis is unclear.
In addition to symptoms and signs caused by the presence of a mass, struma may be associated with a number of unusual clinical manifestations.
Struma ovarii is rare ovarian tumour that is characterized by the presence of at least 50% thyroid tissue on histologic examination.
The presence of thyroid tissue in the ovary implies either metastatic thyroid carcinoma, or a monophyletic teratoma such as "struma ovarii".
Always look out for other teratomatous elements,especially carcinoid tumour which is specifically associated with thyroid tissue in the ovary.
The thyroid tissue here can be affected by the full range of disease processes which would otherwise affect the native thyroid gland.
Interpretation of malignant transformation in the tissue is difficult, but for papillary carcinoma, the criteria are the same as for the thyroid gland.
If the patient develops autoimmune thyroiditis, the "struma ovarii" shows similar changes in the native gland.
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