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Pathology of Syringofibroadenoma

Dr Sampurna Roy MD        


Path Quiz Case 74:  Case history and images

Diagnosis: Syringofibroadenoma




Eccrine syringofibroadenoma is a rare eccrine tumour first described by Mascaro in 1963.

Clinical presentation:  Solitary, often large nodular lesion. These are most often found in middle-aged and elderly patients.

Site:  Usually located on the extremities and rarely on the face.

Microscopic features: 

Histologic examination reveal branching anastomosing strands of epithelial cells with ductal structures in a fibrovascular stroma. 

Epithelial strands are attached to the undersurface of the epidermis.

The luminal cells show positive staining for carcinoembryonic antigen.

A few cases with this pattern have been associated with carcinoma (syringofibrocarcinoma).

Variant:  The clear cell variant was reported by Fretzin in 1995. 

It is characterized by nests of periodic acid Schiff-positive clear cells resembling the clear-cell variant of syringoma.


Multiple (palmoplantar) Eccrine syringofibroadenomas are a new cutaneous marker of the Schopf syndrome - (hidrocystomas of the eyelid, hypotrichosis- less than normal amount of hair on the head or body, hypodontia- fewer than the normal number of teeth, and nail abnormalities).

Reactive Eccrine Syringofibroadenomatosis -  May occur next to various condition.  

Example- Inflammatory dermatosis, bullous pemphigus,  palmoplantar erosive lichen planus and chronic diabetic foot ulcers.


Further reading:

Solitary eccrine syringofibroadenoma arising on the toe.

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Eccrine syringofibroadenoma of the eyelid.

Clouston syndrome and eccrine syringofibroadenomas.

Eccrine syringofibroadenoma-like change adjacent to a squamous cell carcinoma: potential histologic pitfall in Mohs micrographic surgery.

Eccrine syringofibroadenoma associated with well-differentiated squamous cell carcinoma.

Eccrine syringofibroadenoma of clear cell variant: an immunohistochemical study.

Eccrine syringofibroadenoma arising in peristomal skin: a report of two cases.

Eccrine syringofibroadenoma: case report and review of the literature.

A case of subungual reactive eccrine syringofibroadenoma.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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